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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (R's) » Ramipril


USE IN PREGNANCY: When used in pregnancy during the second and third trimesters, ACE inhibitors can cause injury and even death to the developing fetus. When pregnancy is detected, ramipril should be discontinued as soon as possible. (See WARNINGS, Fetal/neonatal morbidity and mortality.)


Ramipril is a 2-aza-bicyclo [3.3.0]-octane-3-carboxylic acid derivative. It is a white, crystalline substance soluble in polar organic solvents and buffered aqueous solutions. Ramipril melts between 105°C and 112°C.

The CAS Registry Number is 87333-19-5. Ramipril's chemical name is (2S,3aS,6aS)-1[(S)-N-[(S)-1-Carboxy-3-phenylpropyl]alanyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid, 1-ethyl ester.

Its empiric formula is C23H32N2O5, and its molecular weight is 416.5.

Ramiprilat, the diacid metabolite of ramipril, is a non-sulfhydryl angiotensin converting enzyme inhibitor. Ramipril is converted to ramiprilat by hepatic cleavage of the ester group.

Altace (ramipril) is supplied as hard shell capsules for oral administration containing 1.25 mg, 2.5 mg, 5 mg, and 10 mg of ramipril. The inactive ingredients present are pregelatinized starch NF, gelatin, and titanium dioxide. The 1.25 mg capsule shell contains yellow iron oxide, the 2.5 mg capsule shell contains D&C yellow #10 and FD&C red #40, the 5 mg capsule shell contains FD&C blue #1 and FD&C red #40, and the 10 mg capsule shell contains FD&C blue #1.


CATEGORIES: Heart failure, congestive; Hypertension, essential; Pregnancy Category D; FDA Class 1C ("Little or No Therapeutic Advantage"); FDA Approved 1991 Jan; Top 200 Drugs

FDA Drug Classes: Ace Inhibitors; Antihypertensives


BRAND NAMES: Altace; Cardace; Delix; Hytren; Pramace; Quark; Ramace; Triatec; Tritace; Unipril, Vesdil
(Foreign Brand names outside U.S. in italics)

Cardace (India)
Delix (Germany)
Hytren (Austria)
Pramace (Sweden)
Quark (Italy)
Ramace (Australia; Belgium; Denmark; Finland; Korea; Mexico; Netherlands; Philippines; South-Africa; Thailand)
Triatec (Denmark; France; Greece; Indonesia; Ireland; Italy; Portugal; Sweden; Switzerland)
Tritace (Australia; Austria; Bahamas; Barbados; Belgium; Belize; Bermuda; Costa-Rica; Curacao; Czech-Republic; Denmark; Dominican-Republic; El-Salvador; England; England; Guatemala; Guyana; Honduras; Hong-Kong; Ireland; Ireland; Israel; Jamaica; Korea; Malaysia; Mexico; Netherland-Antilles; Netherlands; New-Zealand; Nicaragua; Panama; Philippines; South-Africa; Surinam; Taiwan; Thailand; Trinidad)
Unipril (Italy)
Vesdil (Germany)

COST OF THERAPY: $354.05 (Hypertension; Altace Capsule; 2.5 mg; 1/day; 365 days)

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