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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (R's) » Ropivacaine



DESCRIPTION

Naropin (ropivacaine HCl Injection) is a member of the amino amide class of local anesthetics. Naropin injections are sterile, isotonic solutions that contain the enantiomerically proof drug substance, sodium chloride for isotonicity and Water for Injection. Sodium hydroxide and/or hydrochloric acid may be used for pH adjustment. These solutions are administered parenterally.

Naropin contains ropivacaine HCl which is chemically described as S-(-)-1-propyl-2',6'-pipecoloxylidide hydrochloride monohydrate. The drug substance is a white crystalline powder, with a chemical formula of C17H26N2O·HCl·H2O and molecular weight of 328.89.

At 25°C ropivacaine HCl has a solubility of 53.8 mg/mL in water, a distribution ratio between n-octanol and phosphate buffer at pH 7.4 of 141 and a pKa of 8.07 in 0.1 M KCl solution. The pKa of ropivacaine is approximately the same as bupivacaine (8.1) and is similar to that of mepivacaine (7.7). However, ropivacaine has an intermediate degree of lipid solubility compared to bupivacaine and mepivacaine.

Naropin is preservative free and is available in single dose containers in 2.0, 5.0, 7.5 and 10.0 mg/mL concentrations. The specific gravity of Naropin solutions range from 1.002 to 1.005 at 25°C.





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