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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (S's) » Salmeterol Xinafoate (inhalation powder)


SEREVENT DISKUS (salmeterol xinafoate inhalation powder) contains salmeterol xinafoate as the racemic form of the 1-hydroxy-2-naphthoic acid salt of salmeterol. The active component of theformulation is salmeterol base, a highly selective beta2-adrenergic bronchodilator. The chemical name of salmeterol xinafoate is;


The molecular weight of salmeterol xinafoate is 603.8, and the empirical formula is C25H37NO4C11H8O3.
Salmeterol xinafoate is a white to off-white powder. It is freely soluble in methanol; slightly soluble in ethanol, chloroform, and isopropanol; and sparingly soluble in water.

SEREVENT DISKUS is a specially designed plastic device containing a double-foil blister strip of a powder formulation of salmeterol xinafoate intended for oral inhalation only. Each blister on the double-foil strip within the device contains 50 mcg of salmeterol administered as the salmeterol xinafoate salt in 12.5 mg of formulation containing lactose. When a blister containing medication is opened by activating the device, the medication is dispersed into the air stream created when the patient inhales through the mouthpiece.

The amount of drug delivered to the lung will depend on patient factors such as inspiratory flow. Under standardized in vitro testing, SEREVENT DISKUS delivers 47 mcg when tested at 60 L/min flow rate for 3 seconds. In adult patients with obstructive lung disease and severely compromised lung function (mean forced expiratory volume in 1 second [FEV1] 0.65 L [range, 0.35 to 0.92 L], 20% to 30% predicted FEV1), mean peak inspiratory flow (PIF) through SEREVENT DISKUS was 82.4 L/min (range, 46.1 to 115.3 L/min). The emitted dose of salmeterol xinafoate determined in an in vitro experiment modeling these patient-generated flow rates was 46 mcg (range, 45 to 51 mcg).

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