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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (S's) » Secretin


Secretin is a gastrointestinal peptide hormone that was first extracted from porcine duodenum by Jorpes & Mutt (1961). The heptacosa-peptide was subsequently sequenced and synthesized by Mutt, Bodansky and their co-workers at the Karolinska Institute. Secretin-Ferring is a highly purified naturally occurring porcine hormone with a potency of not less than 3000 clinical units (CU) per mg peptide. Secretin is chemically defined as follows:

Molecular Weight: 3055.5

Empirical Formula: C13OH22ON44O41

Structural Formula: H-His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu-Ser-Arg-Leu-Arg-Asp-Ser-Ala-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Gly-Leu-Val-NH2

Secretin-Ferring contains 75 CU of lyophilized, sterile purified secretin, 1 mg of L-cysteine hydrochloride, and 20 mg of mannitol per vial. When reconstituted in 7.5 ml of Sodium Chloride Injection USP, each ml of solution contains 10 CU secretin for intravenous use. The pH of the reconstituted solution has a range of 2.5-5.0.

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