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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (S's) » Sibutramine


MERIDIA (sibutramine hydrochloride monohydrate) is an orally administered agent for the treatment of obesity. Chemically the active ingredient is a racemic mixture of the and enantiomers of cyclobutanemethanamine 1-(4- chlorophenyl)-N , N - dimethyl - alfa - (2-methylpropyl)-, hydrochloride, monohydrate, and has an empirical formula of C17H 29Cl 2NO. Its molecular weight is 334.33. Sibutramine hydrochloride monohydrate is a white to cream crystalline powder with a solubility of 2.9 mg/ mL in pH 5.2 water. Its octanol water partition coefficient is 30.9 at pH 5.0

Each MERIDIA capsule contains 5 mg, 10 mg and 15 mg of sibutramine hydrochloride monohydrate. It also contains as inactive ingredients: lactose monohydrate NF; microcrystalline cellulose NF; colloidal silicon dioxide NF; and magnesium stearate NF in a hard gelatin capsule, which contains titanium dioxide USP; gelatin FD&C Blue No.2 (5 and 10 mg capsules only); D&C Yellow No.10 (5 and 15 mg capsules only) and other inactive ingredients.

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