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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (S's) » Simvastatin


Simvastatin is a lipid-lowering agent that is derived synthetically from a fermentation product of Aspergillus terreus. After oral ingestion, simvastatin, which is an inactive lactone, is hydrolyzed to the corresponding b-hydroxyacid form. This is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. This enzyme catalyzes the conversion of HMG-CoA to mevalonate, which is an early and rate-limiting step in the biosynthesis of cholesterol.

Simvastatin is butanoic acid, 2,2-dimethyl-,1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)-ethyl]-1-naphthalenyl ester, [1S*-[1a,3a,7b,8b(2S*,4S),-8ab]]. The empirical formula of simvastatin is C25H38O5 and its molecular weight is 418.57.

Simvastatin is a white to off-white, nonhygroscopic, crystalline powder that is practically insoluble in water, and freely soluble in chloroform, methanol, and ethanol.

Tablets Zocor for oral administration contain either 5 mg, 10 mg, 20 mg, 40 mg or 80 mg of simvastatin and the following inactive ingredients: cellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, iron oxides, lactose, magnesium stearate, starch, talc, titanium dioxide, and other ingredients. Butylated hydroxyanisole is added as a preservative.


CATEGORIES: Hypercholesterolemia; Hyperlipidemia; Hyperlipoproteinemia; Hypertriglyceridemia; Pregnancy Category X; FDA Class 1C ("Little or No Therapeutic Advantage"); FDA Approved 1991 Dec; Top 200 Drugs

FDA Drug Classes: Hyperlipidemia


BRAND NAMES: Cholestat; Denan; Kolestevan; Lipex; Lipinorm; Liponorm; Lipovas; Lodales; Modutrol; Nor-Vastina; Rechol; Simcor; Simovil; Simvotin; Sinvacor; Sivastin; Statin; Valemia; Zocor; Zocord
(Foreign Brand names outside U.S. in italics)

Cholestat (Indonesia)
Denan (Germany)
Kolestevan (Costa-Rica)
Lipex (Australia)
Lipinorm (Indonesia)
Liponorm (Italy)
Lipovas (Japan)
Lodales (France)
Modutrol (Peru)
Nor-Vastina (El-Salvador)
Rechol (Indonesia)
Simcor (Indonesia)
Simovil (Israel)
Simvotin (India)
Sinvacor (Italy)
Sivastin (Italy)
Statin (Colombia)
Valemia (Indonesia)
Zocord (Austria; Sweden)

COST OF THERAPY: $649.70 (Hypercholesterolemia; Zocor Tablet; 5 mg; 1/day; 365 days)

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