Sulindac is a non-steroidal, anti-inflammatory indene derivative designated
chemically as (Z)-5-fluoro-2-methyl-1[[p-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic
acid. It is not a salicylate, pyrazolone or propionic acid derivative.
Sulindac, a yellow crystalline compound is a weak organic acid practically
insoluble in water below pH 4.5, but very soluble as the sodium salt or
in buffers of pH 6 or higher.
It has the following molecular formula: C20H17FO3S
with a molecular weight of 356.42.
Sulindac is available in 150 mg or 200 mg tablets for oral administration.
Each tablet contains the following inactive ingredients: magnesium stearate,
microcrystalline cellulose, starch (corn) and stearic acid.
Following absorption, sulindac undergoes two major biotransformations
reversible reduction to the sulfide metabolite and irreversible oxidation
to the sulfone metabolite. Available evidence indicates that the biological
activity resides with the sulfide metabolite.