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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (S's) » Sumatriptan Succinate (intranasal)


Sumatriptan is a selective 5-hydroxytryptamine1 receptor subtype agonist. Sumatriptan is chemically designated as 3-[2-(dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulfonamide.

The empirical formula is C14H21N3O2S, representing a molecular weight of 295.4. Sumatriptan is a white to off-white powder that is readily soluble in water and saline. Each Imitrex nasal spray contains 5 or 20 mg of sumatriptan in a 100-ml unit dose aqueous buffered solution containing monobasic potassium phosphate, anhydrous dibasic sodium phosphate, sulfuric acid, sodium hydroxide, and purified water. The pH of the solution is approximately 5.5. The osmolality of the solution is 372 or 742 mOsmol for the 5- and 20-mg Imitrex nasal spray, respectively.


CATEGORIES: Headache, migraine; Pregnancy Category C; FDA Class 1P ("Priority Review"); Top 200 Drugs; FDA Approved 1992 Dec

FDA Drug Classes: Antimigraine; Pharmaceutical Aids


BRAND NAMES: Imigran; Imigrane; Imiject; Imitrex; Megrelan; Migragesin; Sumitrex
(Foreign Brand names outside U.S. in italics)

Imigrane (France)
Imiject (France)
Megrelan (Colombia)
Migragesin (Colombia)
Sumitrex (India)

HCFA JCODE(S): J3030 6 mg SC

COST OF THERAPY: $98.69 (Migraine; Imitrex Solution; 6 mg/0.5 ml; 1/day; 1 days)

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