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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (S's) » Synvisc


Synvisc® (hylan G-F 20) is an elastoviscous fluid containing hylan polymers produced from chicken combs. Hylans are derivatives of hyaluronan (sodium hyaluronate), a natural complex sugar of the glycosaminoglycan family. Hyaluronan is a long-chain polymer containing repeating disaccharide units of Na-glu-curonate-N-acetylglucosamine.


Synvisc contains hylan A (average molecular weight 6,000,000) and hylan B hydrated gel in a buffered physiological sodium chloride solution, pH 7.2. Synvisc has an elasticity (storage modulus G') at 2.5 H of 111 13 Pascals (Pa) and a viscosity (loss modulus G") of 25 2 Pa (elasticity and viscosity of knee synovial fluid of 18 to 27-year-old humans measured with a comparable method at 2.5 Hz:
G' = 117 13 Pa; G" = 45 8 Pa.)
Each syringe of Synvisc contains:

Hylan polymers (hylan A + hylan B) 16 mg
Sodium chloride 17 mg
Disodium hydrogen phosphate 0.32 mg
Sodium dihydrogen phosphate monohydrate 0.08 mg
Water for injection q.s. to 2.0 mL

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