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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (T's) » Tamoxifen Citrate



DESCRIPTION

Tamoxifen citrate tablets, a nonsteroidal antiestrogen, are for oral administration. Nolvadex tablets are available as:

10 mg Tablets: Each 10 mg tablet contains 15.2 mg of tamoxifen citrate which is equivalent to 10 mg of tamoxifen.

20 mg Tablets: Each 20 mg tablet contains 30.4 mg of tamoxifen citrate which is equivalent to 20 mg of tamoxifen.

Inactive Ingredients: Carboxymethylcellulose calcium, magnesium stearate, mannitol and starch.

Chemically, tamoxifen is the trans-isomer of a triphenylethylene derivative. The chemical name is (Z)2-[4-(1,2-diphenyl-1-butenyl) phenoxy]-N, N-dimethylethanamine 2-hydroxy-1,2,3- propanetricarboxylate (1:1).

Tamoxifen citrate has a molecular weight of 563.62, the pKa' is 8.85, the equilibrium solubility in water at 37°C is 0.5 mg/ml and in 0.02 N HCl at 37°C, it is 0.2 mg/ml.

CATEGORIES, BRAND NAMES

CATEGORIES: Carcinoma, breast; Pregnancy Category D; WHO Formulary; FDA Approved 1994 Mar; Top 200 Drugs

FDA Drug Classes: Antineoplastics; Hormonal/Biological Response Modifiers

BRAND NAMES:

BRAND NAMES: Dignotamoxi; Istubol; Kessar; Mamofen; Noltam; Nolvadex; Novofen; Tamaxin; Tamifen; Tamofen; Tamoplex; Tamoxen; Valodex; Zitazonium

COST OF THERAPY: $1284.80 (Ovarian Carcinoma; Nolvadex Tablet; 10 mg; 2/day; 365 days)





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