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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (T's) » Testosterone (transdermal)



DESCRIPTION

TESTODERM®TTS, TESTODERM® and TESTODERM® WITH ADHESVIE Testosterone Transdermal Systems (referred to collectively as the TESTODERM® products) are designed to release controlled amounts of testosterone, the primary circulating endogenous androgen, continuously upon application to the arm, back or upper buttocks (TESTODERM®TTS) or scrotal skin (TESTODERM® and TESTODERM® WITH ADHESVIE). The TESTODERM® products are described below.

Product

Dose
(mg/day)

Size
(cm2)

Application Site

Testoderm® TTS

5

60

Arm, Back, Upper Buttocks

Testoderm®*

5

60

Scrotum

Testoderm®*

4

40

Scrotum

Testoderm® with
Adhesive

6

60

Scrotum


* The composition of the two sizes per unit area is identical.

The active component of each of the systems is testosterone. Testosterone USP is a white or creamy-white crystalline powder or crystals chemically described as 17-beta hydroxyandrost-4-en-3-one. The remaining components of the systems are pharmacologically inactive.

TESTODERM® TTS is composed of the following layers: a flexible backing of polyester/ethylene-vinyl acetate copolymer film, a drug reservoir of testosterone USP and 1.2 mL alcohol USP gelled with hydroxypropyl cellulose, and an ethylene-vinyl acetate copolymer membrane coated with a layer of a polyisobutylene adhesive formulation that controls the rate of release of testosterone from the system. A protective liner of silicone-coated polyester covers the adhesive surface. The liner must be removed before application.

TESTODERM® is composed of two layers: a soft flexible backing of polyester and a testosterone-containing film of ethylene-vinyl acetate copolymer that contacts the skin surface and modulates the availability of the steroid. A protective liner of fluorocarbon diacrylate or silicone-coated polyester covers the drug film. The liner must be removed before application.

TESTODERM® WITH ADHESVIE is composed of three layers: a soft flexible backing of polyester and a testosterone-containing film of ethylene-vinyl acetate copolymer. The surface of the drug film is partially covered by the third layer: thin and narrow adhesive stripes composed of polyisobutylene and colloidal silicon dioxide. A protective liner of fluorocarbon diacrylate covers the adhesive stripes and the adhesive-free area of the drug film. The liner must be removed before application.

The active component of the systems is testosterone. The remaining components of the systems are pharmacologically inactive.





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