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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (T's) » Testosterone Transdermal System- RxList Monographs




Androderm (testosterone transdermal system) provides continuous delivery of testosterone (the primary endogenous androgen) for 24 hours following application to intact, nonscrotal skin (e.g., back, abdomen, thighs, upper arms). Two strengths of Androderm are available which deliver in vivo 2.5 mg or 5 mg of testosterone per day across skin of average permeability. Androderm has a central drug delivery reservoir surrounded by a peripheral adhesive area. The Androderm 2.5 mg system has a total contact surface area of 37 cm2 with a 7.5 cm2 central drug delivery reservoir containing 12.2 mg testosterone USP, dissolved in an alcohol-based gel. The Androderm 5 mg system has a total contact surface area of 44 cm2 with a 15 cm2 central drug delivery reservoir containing 24.3 mg testosterone USP, dissolved in an alcohol-based gel. Testosterone USP is a white, or creamy white crystalline powder or crystals chemically described as 17b-hydroxyandrostd-en-3-one.

The Androderm systems have six components. Proceeding from the top toward the surface attached to the skin, the system is composed of

  1. Metallized polyester/SurlynÒ (ethylene-meth-acrylic acid copolymer)/ethyl vinyl acetate backing film.
  2. A drug reservoir of testosterone USP, alcohol USP, glycerin USP, glycerol monooleate, and methyl laurate gelled with an acrylic acid copolymer.
  3. A permeable polyethylene microporous membrane.
  4. A peripheral layer of acrylic adhesive surrounding the central, active drug delivery area of the system. Prior to opening of the system and application to the skin, the central delivery surface of the system is sealed with a peelable laminate disc.
  5. Composed of a five-layer laminate containing polyester/polyesterurethane adhesive/aluminum foillpolyesterurethane adhesive/polyethylene. The disc is attached to and removed with the release liner.
  6. A silicone-coated polyester film, which is removed before the system can be used.

The active ingredient in the system is testosterone. The remaining components of the system are pharmacologically inactive.

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