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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (T's) » Theophylline



DESCRIPTION

Theophylline is structurally classified as a methylxanthine. It occurs as a white, odorless, crystalline powder with a bitter taste. Anhydrous theophylline has the chemical name 1H-Purine-2,6-dione,3,7-dihydro-1,3-dimethyl-.

The molecular formula of anhydrous theophylline is C7H8N4O2 with a molecular weight of 180.17. (For products containing theophylline monohydrate, substitute the following: The molecular formula of theophylline monohydrate is C7H8N4O2H2O with a molecular weight of 198.18.)

The molecular formula of oxtriphylline is C12H21N5O3 with a molecular weight of 283.33.

Immediate-Release Oral Forms

Slo-Phyllin tablets (theophylline tablets, USP) are scored, dye-free tablets providing 100 mg or 200 mg of theophylline, anhydrous, USP.

Slo-Phyllin 80 mg Syrup (theophylline, anhydrous) is a nonalcoholic, sugar-free solution containing per 15 ml theophylline, anhydrous, USP 80 mg with sodium benzoate, NF, 18 mg and methylparaben, NF 3 mg added as preservatives.

Both tablets and syrup are intended for oral administration. Theophylline is a bronchodilator structurally classified as a xanthine derivative.

Syrup inactive ingredients are citric acid, flavors, glycerine, methylparaben, propylene glycol, saccharin sodium, sodium benzoate, sorbitol, purified water.

Tablets: 100 mg inactive ingredients are lactose, magnesium stearate, microcrystalline cellulose, sodium starch glycolate; 200 mg inactive ingredients are magnesium stearate, microcrystalline cellulose, sodium starch glycolate.

Sustained Action Capsules

Theo-Dur Sprinkle sustained action capsules contain 50 mg, 75 mg, 125 mg, or 200 mg anhydrous theophylline, a bronchodilator structurally classified as a xanthine derivative. The inactive ingredients for Theo-Dur Sprinkle are: ethylcellulose, hydroxypropylcellulose, povidone, and sucrose. Theo-Dur Sprinkle takes the form of long-acting microencapsulated beads within a hard gelatin capsule for oral administration.

The theophylline has been microencapsulated in a proprietary coating of polymers to mask the bitter taste associated with the drug while providing a prolonged effect. The entire contents of a Theo-Dur Sprinkle capsule are intended to be sprinkled on a small amount of soft food immediately prior to ingestion, or it may be swallowed whole. SUBDIVIDING THE CONTENTS OF A CAPSULE IS NOT RECOMMENDED. Each capsule is oversized to allow ease of opening.

Anhydrous theophylline is a white, odorless, crystalline powder having a bitter taste.

CATEGORIES, BRAND NAMES

CATEGORIES: Asthma; Bronchitis, Chronic; Bronchitis; Bronchospasm; Emphysema; Obstruction, Airway; Pregnancy Category C; FDA Approved 1979 Apr; WHO Formulary

FDA Drug Class: Anesthesia, Adjuncts To/Analeptics; Antiasthmatics/Broncodilators; Antitussives/Expectorants/Mucolytics

BRAND NAMES: Accurbron; Aerobin; Aerodyne Retard; Aerolate; Aldefilina; Almarion; Aloefilina; Amilex; Aminomal; Aquaphyllin; Armophylline; Asmalix; Asmasalon; Asperal; Asperal-T; Austyn; Bilordyl; Bronchoretard; Bronkodyl; Bronsolvan; Bykofilin; Bykofilin Retard; Constant-T; Cronasma; Diffumal; Duraphyl; Elixicon; Elixofilina; Elixomin; Elixophyllin; Euphyllin Retard; Euphylong; Euphylong SR; Godafilin; Hydro-Spec; Labid; Lanophyllin; Lasma; Lixolin; Nefoben; Neulin-SA; Neulin-SR; Neulin SA; Nuelin; Nuelin SA; Nuelin SR; Pharphylline; Phyllocontin; Phylobid; PMS Theophylline; Provent; Pulmidur; Pulmo; Pulmo-Timelets; Pulmo; Quibran T SR; Quibron T SR; Respbid; Slo-Bid; Slo-Phyllin; Solosin; Solu-Phyllin; Somofillina; Somophyllin; Sustaire; T-Phyl; Talofren; Talotren; Teoclear; Teoclear LA; Teofilina; Teofilina Retard; Teolixir; Teolong; Teophyllin; Teosona; Theo-2; Theo-24; Theo-Bros; Theo-Dur; Theo-Time; Theo PA; Theobid; Theochron; Theoclear; Theocontin; Theocot; Theolair; Theolair S; Theolair S.R.; Theolan; Theomar; Theomax; Theon; Theophyl; Theophylline Anhydrous; Theoplus; Theoplus Retard; Theosol-80; Theospan Sr; Theospirex Retard; Theostat ; Theostat LP; Theostat 80; Theotard; Theotrim; Theovent; Theovent LA; Theo von CT; Theox; Tiodilax; Truxophyllin; Unicontin-400 Continus; Uni-Dur; Unifyl; Unifyl Retard; Uniphyl; Uniphyllin; Uniphyllin Continus; Xantivent
(Foreign brand names outside U.S. in italics)

Cost of Therapy: $117.16 (Asthma; Tablet; 200 mg; 3/day; 365 days)





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