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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (T's) » Thiotepa (injection)


Thioplex® (thiotepa for injection) is an ethylenimine-type compound. It is supplied as a non-pyrogenic, sterile lyophilized powder for intravenous, intracavitary or intravesical administration, containing 15 mg of thiotepa. Thioplex is a synthetic product with antitumor activity. The chemical name for thiotepa is Aziridine, 1,1',1"-phosphinothioylidynetris-, or Tris (1-aziridinyl) phosphine sulfide. 

Thiotepa has the empirical formula C6H12N3PS and a molecular weight of 189.22. When reconstituted with Sterile Water for Injection, the resulting solution has a pH of approximately 5.5 - 7.5. Thiotepa is stable in alkaline medium and unstable in acid medium. 

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