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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (T's) » Trimetrexate


Neutrexin is the brand name for trimetrexate glucuronate. Trimetrexate, a 2,4-diaminoquinazoline, non-classical folate antagonist, is a synthetic inhibitor of the enzyme dihydrofolate reductase (DHFR). Neutrexin is available as a sterile lyophilized powder in single-dose vials, each containing trimetrexate glucuronate equivalent to 25 mg of trimetrexate without any preservatives or excipients. The powder is reconstituted prior to intravenous infusion (see DOSAGE AND ADMINISTRATION, RECONSTITUTION AND DILUTION).

Trimetrexate glucuronate is chemically known as 2,4-diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]
quinazoline mono-D-glucuronate.

The empirical formula for trimetrexate glucuronate is C19H23N5O3C6H 10O7 with a molecular weight of 563.56. The active ingredient, trimetrexate free base, has an empirical formula of C19H23N5O3 with a molecular weight of 369.42. Trimetrexate glucuronate for injection is a pale greenish-yellow powder or cake. Trimetrexate glucuronate is soluble in water (>50 mg/mL), whereas trimetrexate free base is practically insoluble in water (<0.1 mg/mL). The pKa of trimetrexate free base in 50% methanol/water is 8.0. The logarithm10 of the partition coefficient of trimetrexate free base between octanol and water is 1.63.

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