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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (T's) » Typhoid Vi Polysaccharide Vaccine


Typhim Vi , Typhoid Vi Polysaccharide Vaccine, produced by Pasteur Mérieux Sérums & Vaccins S. A., for intramuscular use, is a sterile solution containing the cell surface Vi polysaccharide extracted from Salmonella typhi Ty2 strain. The organism is grown in a semi-synthetic medium without animal proteins. The capsular polysaccharide is precipitated from the concentrated culture supernatant by the addition of hexadecyltrimethylammonium bromide and the product is purified by differential centrifugation and precipitation. The potency of the purified polysaccharide is assessed by molecular size and O-acetyl content. Phenol, 0.25%, is added as a preservative. The vaccine contains residual polydimethylsiloxane or fatty-acid ester-based antifoam. The vaccine is a clear, colorless solution. Each single-dose of 0.5 mL is formulated to contain 25 µg of purified Vi polysaccharide in a colorless isotonic phosphate buffered saline (pH 7 ± 0.3), 4.150 mg of Sodium Chloride, 0.065 mg of Disodium Phosphate (2H 2 0), 0.023 mg of Monosodium Phosphate and 0.5 mL of Sterile Water for Injection.

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