|Use In Pregnancy: When used in pregnancy during
the second and third trimesters, drugs that act
directly on the renin-angiotensin system can cause
injury and even death
to the developing fetus. When pregnancy is detected, valsartan
should be discontinued as soon as possible. See WARNINGS,
Fetal/Neonatal Morbidity and Mortality.
Diovan is a nonpeptide, orally active, and specific
angiotensin II antagonist
acting on the AT1 receptor
Valsartan is chemically described as N-(1-oxopentyl)-N-[[2¢-(1H-tetrazol-5-yl)[1,1¢-biphenyl]-4-yl]methyl]-L-valine.
Its empirical formula
is C24H29N5O3, and its molecular
weight is 435.5.
Valsartan is a white to practically
white fine powder. It is soluble
in ethanol and methanol
and slightly soluble in water.
Diovan is available as capsules for oral
administration, containing either 80 mg or 160 mg of valsartan. The inactive
insredients of the capsules are cellulose
compounds, crospovidone, gelatin, iron
oxides, magnesium stearate, povidone, sodium
lauryl sulfate, and titanium
CATEGORIES, BRAND NAMES
CATEGORIES: Hypertension, essential; Pregnancy Category
C, 1st Trimester; Pregnancy Category D, 2nd & 3rd Trimesters; FDA
Approved 1996 Feb; Patent Expiration 2012 Mar; Top 200 Drugs
FDA Drug Classes: Ace Inhibitors
BRAND NAMES: Diovan; Nisis; Tareg
(Foreign Brand names outside U.S. in italics)
FOREIGN BRAND AVAILABILITY: