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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (V's) » Venlafaxine



DESCRIPTION

Venlafaxine hydrochloride is a structurally novel antidepressant for oral administration. It is chemically unrelated to tricyclic, tetracyclic, or other available antidepressant agents. It is designated (R/S)-1-[2-(dimethylamino)-1-(4 methoxyphenyl)ethyl] cyclohexanol hydrochloride or (±)-1-[a [(dimethylamino)methyl] p-methoxybenzyl] cyclohexanol hydrochloride and has the empirical formula of C17H27NO2 HCl. Its molecular weight is 313.87.

Venlafaxine hydrochloride is a white to off-white crystalline solid with a solubility of 572 mg/ml in water (adjusted to ionic strength of 0.2 M with sodium chloride). Its octanol:water (0.2 M sodium chloride) partition coefficient is 0.43.

Effexor: Compressed tablets contain venlafaxine hydrochloride equivalent to 25 mg, 37.5 mg, 50 mg, 75 mg, or 100 mg venlafaxine. Inactive ingredients consist of cellulose, iron oxides, lactose, magnesium stearate, and sodium starch glycolate.

Effexor XR: Effexor XR is formulated as an extended release capsule for once-a-day oral administration. Drug release is controlled by diffusion through the coating membrane on the spheroids and is not pH dependent. Capsules contain venlafaxine hydrochloride equivalent to 37.5 mg, 75 mg, or 150 mg venlafaxine. Inactive ingredients consist of cellulose, ethylcellulose, gelatin, hydroxypropyl methylcellulose, iron oxide, and titanium dioxide.

CATEGORIES, BRAND NAMES

CATEGORIES: Depression; FDA Class 1S ("Standard Review"); FDA Approved 1993 Dec; Pregnancy Category C; Top 200 Drugs

FDA Drug Classes: Antidepressants

BRAND NAMES:

BRAND NAMES: Efexor; Efexor XR; Effexor; Trevilor; Trewilor
(Foreign Brand names outside U.S. in italics)

FOREIGN BRAND AVAILABILITY:
Efexor (Australia; Austria; Canada; Colombia; Denmark; England; Greece; Hong-Kong; Israel; Korea; Mexico; Netherlands; South-Africa; Sweden; Switzerland)
Efexor XR (Canada)
Trevilor (Germany; Switzerland)





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