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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (W's) » Warfarin



DESCRIPTION

Crystalline warfarin sodium, is an anticoagulant which acts by inhibiting vitamin K-dependent coagulation factors. Chemically, it is 3- (a-acetonylbenzyl) -4 -hydroxycoumarin and is a racemic mixture of the R and S enantiomers. Crystalline warfarin sodium is an isopropanol clathrate. The crystallization of warfarin sodium virtually eliminates trace impurities present in amorphous warfarin sodium. Its empirical formula is C19H15NaO4.

Crystalline warfarin sodium occurs as a white, odorless, crystalline powder, is discolored by light and is very soluble in water; freely soluble in alcohol; very slightly soluble in chloroform and in ether.

Coumadin Tablets

Coumadin Tablets for Oral Use Also Contain: All strengths: Lactose, starch and magnesium stearate; 1 mg: D&C Red 6; 2 mg: FD&C Blue 2 and FD&C Red 40; 2-1/2 mg: FD&C Blue 1 and D&C Yellow 10; 4 mg: FD&C Blue 1 Lake; 5 mg: FD&C Yellow 6; 7-1/2 mg: D&C Yellow 10 and FD&C Yellow 6; 10 mg: Dye Free.

Coumadin for Injection

Coumadin for Injection is supplied as a sterile, lyophilized powder, which, after reconstitution with 2.7 ml sterile Water for Injection, contains: Warfarin sodium: 2 mg/ml; Sodium Phosphate, Dibasic, Heptahydrate: 4.98 mg/ml; Sodium Phosphate, Monobasic, Monohydrate: 0.194 mg/ml Sodium Chloride: 0.1 mg/ml; Mannitol: 38.0 mg/ml; Sodium Hydroxide, as needed for pH adjustment to: 8.1 to 8.3.

CATEGORIES, BRAND NAMES

CATEGORIES: Arrhythmia, atrial fibrillation, adjunct; Embolism, pulmonary; Infarction, myocardial; Prevention, stroke; Thrombosis, deep vein; Pregnancy Category X; FDA Approved 1955 Nov; Top 200 Drugs; WHO Formulary

FDA Drug Classes: Anticoagulants

BRAND NAMES:

BRAND NAMES: Aldocumar; Athrombin; Coumadan Sodico; Coumadin; Coumadine; Dimantil; Farin; Marevam; Marevan; Orfarin; Panwarfin; Simarc-2; Sofarin; UniWarfin; Waran; Warfarina; Warfil 5; Warfilone
(Foreign Brand names outside U.S. in italics)

FOREIGN BRAND AVAILABILITY:
Aldocumar (Spain)
Coumadan Sodico (Argentina)
Coumadine (France)
Dimantil (Mexico)
Farin (Thailand)
Marevan (Australia; Belgium; Denmark; England; Finland; New-Zealand; Norway)
Orfarin (Malaysia; Thailand)
Simarc-2 (Indonesia)
UniWarfin (India)
Waran (Sweden)
Warfil 5 (Dominican-Republic)
Warfilone (Canada)

COST OF THERAPY: $248.20 (Thrombosis; Coumadin Tablet; 5 mg; 1/day; 365 days)





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