CAPOTEN ® (captopril tablets)
USE IN PREGNANCY
When used in pregnancy
during the second and third trimesters, ACE inhibitors can cause
injury and even death
to the developing fetus.
is detected, CAPOTEN should be discontinued as soon as possible.
See WARNINGS: Fetal/Neonatal
Morbidity and Mortality.
CAPOTEN (captopril tablets) is a specific
competitive inhibitor of
angiotensin I-converting enzyme
(ACE), the enzyme responsible
for the conversion of angiotensin
I to angiotensin II.
CAPOTEN is designated chemically as 1-[( 2S)-3-mercapto-2-methylpropionyl]-Lproline
[MW 217.29]. Captopril is a white
to off-white crystalline
powder that may have a slight
sulfurous odor; it is soluble
in water (approx. 160 mg/mL),
methanol, and ethanol and
sparingly soluble in chloroform
and ethyl acetate.
CAPOTEN is available in potencies of 12.5 mg, 25 mg, 50 mg, and 100 mg
as scored tablets for oral administration.
Inactive ingredients: microcrystalline cellulose, corn
starch, lactose, and stearic