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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (C's) » Captopril



CAPOTEN ® (captopril tablets)

USE IN PREGNANCY

When used in pregnancy during the second and third trimesters, ACE inhibitors can cause injury and even death to the developing fetus.

When pregnancy is detected, CAPOTEN should be discontinued as soon as possible.

See WARNINGS: Fetal/Neonatal Morbidity and Mortality.


DESCRIPTION

CAPOTEN (captopril tablets) is a specific competitive inhibitor of angiotensin I-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I to angiotensin II.

CAPOTEN is designated chemically as 1-[( 2S)-3-mercapto-2-methylpropionyl]-Lproline [MW 217.29]. Captopril is a white to off-white crystalline powder that may have a slight sulfurous odor; it is soluble in water (approx. 160 mg/mL), methanol, and ethanol and sparingly soluble in chloroform and ethyl acetate.

CAPOTEN is available in potencies of 12.5 mg, 25 mg, 50 mg, and 100 mg as scored tablets for oral administration. Inactive ingredients: microcrystalline cellulose, corn starch, lactose, and stearic acid.





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