PARAPLATIN ® (carboplatin for injection)
PARAPLATIN ® (carboplatin for injection) should be
administered under the supervision of a qualified physician
experienced in the use of cancer chemotherapeutic agents.
Appropriate management of therapy
and complications is possible only when adequate treatment
facilities are readily available.
is dose related
and may be severe, resulting in infection
and/or bleeding. Anemia may be cumulative
and may require transfusion support. Vomiting is another
frequent drug-related side
Anaphylactic-like reactions to PARAPLATIN have been reported
and may occur within minutes of PARAPLATIN administration.
Epinephrine, corticosteroids, and antihistamines have been
employed to alleviate
PARAPLATIN ® (carboplatin for injection) is supplied as a sterile,
lyophilized white powder
available in single-dose vials containing 50 mg, 150 mg, and 450
mg of carboplatin
by intravenous infusion.
Each vial contains equal
parts by weight of carboplatin
Carboplatin is a platinum
that is used as a cancer chemotherapeutic agent. The chemical
name for carboplatin
is platinum, diammine [1,1-cyclobutanedicarboxylato(2-)-0, 0']-,(SP-4-2).
Carboplatin is a crystalline
powder with the molecular
formula of C6H12N2O4Pt
and a molecular weight
It is soluble in water
at a rate of approximately
14 mg/mL, and the pH of a 1% solution
is 5-7. It is virtually insoluble
in ethanol, acetone, and dimethylacetamide.