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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (C's) » Cephalexin



DESCRIPTION

Keflex is a semisynthetic cephalosporin antibiotic intended for oral administration. It is 7-(D-a-Amino-a-phenylacetamido)- 3-methyl-3-cephem-4-carboxylic acid monohydrate. Cephalexin has the molecular formula C16H17N3O4S·H2O and the molecular weight is 365.41.

The nucleus of cephalexin is related to that of other cephalosporin antibiotics. The compound is a zwitterion; i.e., the molecule contains both a basic and an acidic group. The isoelectric point of cephalexin in water is approximately 4.5 to 5.

The crystalline form of cephalexin which is available is a monohydrate. It is a white crystalline solid having a bitter taste. Solubility in water is low at room temperature; 1 or 2 mg/ml may be dissolved readily, but higher concentrations are obtained with increasing difficulty.

The cephalosporins differ from penicillins in the structure of the bicyclic ring system. Cephalexin has a D-phenylglycyl group as substituent at the 7-amino position and an unsubstituted methyl group at the 3-position.

Each Pulvule contains cephalexin monohydrate equivalent to 250 mg (720 mmol) or 500 mg (1,439 mmol) of cephalexin. The Pulvules also contain cellulose, Dy & C Yellow No. 10, F Dy & C Blue No. 1, F Dy & C Yellow No. 6, gelatin, magnesium stearate, silicone, titanium dioxide, and other inactive ingredients.

Each capsule manufactured by Mylan contains cephalexin monohydrate equivalent to 250 mg (720 mmol) or 500 mg (1,439 mmol) of cephalexin. The capsules also contain cellulose, F Dy & C Blue No. 1, gelatin, magnesium stearate, silicone, titanium dioxide, and other inactive ingredients.

After mixing, each 5 ml of Keflex, for oral suspension, will contain cephalexin monohydrate equivalent to 125 mg (360 mmol) or 250 mg (720 mmol) of cephalexin. The suspensions also contain flavors, methylcellulose, silicone, sodium lauryl sulfate, and sucrose. The 125-mg suspension contains F Dy & C Red No. 40, and the 250-mg suspension contains F Dy & C Yellow No. 6.

Each capsule manufactured by Biocraft contains cephalexin monohydrate equivalent to 250 mg (720 mmol) or 500 mg (1,439 mmol) of cephalexin. Inactive ingredients: magnesium stearate, silicone dioxide and may contain talc. Capsul shell and print constituents: black iron oxide, Dy & C Yellow #10 aluminium lake, FD & C blue #1 aluminium lake, FD & C Blue #2 aluminium lake, FD & C Red #40 aluminium lake, gelatin, pharmaceutical glaze modified in SD-45, silcon dioxide or carbomethylcellulose sodium, sodium lauryl sulfate, titanium dioxide and may contian propylene glyceryl. In addition, the 250 mg capsule shell contains yellow iron oxide.

Each tablet manufactured by Biocraft contains cephalexin monohydrate equivalent to 250 mg (720 mmol) or 500 mg (1,439 mmol) of cephalexin. Inactive ingredients: hydroxypropyl methylcellulose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 90, sodium starch glycolate and titanium dioxide.

CATEGORIES, BRAND NAMES

CATEGORIES: Infection, bone; Infection, ear, middle; Infection, skin and skin structures; Infection, upper respiratory tract; Infection, urinary tract; Prostatitis, acute; Pregnancy Category B; FDA Approval Pre 1982; Top 200 Drugs

FDA Drug Classes: Cephalosporins

BRAND NAMES:

BRAND NAMES: Alcephin; Alexin; Alsporin; Biocef; Carnosporin; Cefablan; Cefadal; Cefadin; Cefadina; Cefadyl; Cefalin; Cefaseptin; Cefax; Ceforal; Cefovit; Celexin; Cepastar; Cepexin; Cephaxin; Cephin; Cepol; Ceporex; Ceporex Forte; Ceporexin; Ceporexine; Ceporexin-E; Cerexin; Check; Cophalexin; Durantel; Durantel DS; Ed A-Ceph; Erocetin; Factagard; Felexin; Fexin; Ibilex; Inphalex; Ibrexin; Kefalex; Kefalospes; Kefaxin; Kefexin; Keflet; Keflex; Kefloridina; Kefolan; Keforal; Kekrinal; Kidolex; Lenocef; Lonflex; Lopilexin; Madlexin; Mamlexin; Mamalexin; Medoxine; Neokef; Novolexin; Nufex; Oracef; Oriphex; Ospexin; Palitrex; Pectril; Pyassan; Refosporen; Relaxin; Roceph; Roceph Distab; Sanaxin; Septilisin; Sepexin; Servispor; Sialexin; Sinthecillin; Sporicef; Sporidex; Synecl; Syncle; Tepaxin; Tokiolexin; Uphalexin; Voxxim; Winlex; Zozarine
(Foreign Brand names outside U.S. in italics)

FOREIGN BRAND AVAILABILITY:
Alcephin (India)
Alexin (India)
Cefablan (Colombia)
Cefadal (Benin; Burkina-Faso; Ethiopia; Gambia; Ghana; Guinea; Ivory-Coast; Kenya; Liberia; Malawi; Mali; Mauritania; Mauritius; Morocco; Niger; Nigeria; Senegal; Seychelles; Sierra-Leone; South-Africa; Sudan; Tanzania; Tunia; Uganda; Zambia; Zimbabwe)
Cefadin (Ecuador)
Cefadina (Spain)
Cefadyl (Benin; Burkina-Faso; Ethiopia; Gambia; Ghana; Guinea; Ivory-Coast; Kenya; Liberia; Malawi; Mali; Mauritania; Mauritius; Morocco; Niger; Nigeria; Senegal; Seychelles; Sierra-Leone; South-Africa; Sudan; Tanzania; Tunia; Uganda; Zambia; Zimbabwe)
Cefalin (Indonesia; Philippines)
Cefax (Colombia)
Ceforal (Israel)
Cefovit (Israel)
Celexin (Thailand)
Cepastar (Philippines)
Cepexin (Austria)
Cephaxin (India)
Cepol (Japan)
Ceporex (Australia; Bahamas; Bahrain; Barbados; Belgium; Belize; Benin; Bermuda; Bulgaria; Burkina-Faso; Canada; Curacao; Cyprus; Czech-Republic; Ecuador; Egypt; England; Ethiopia; Gambia; Ghana; Guinea; Guyana; Hong-Kong; Iran; Iraq; Ireland; Israel; Italy; Ivory-Coast; Jamaica; Jordan; Kenya; Kuwait; Lebanon; Liberia; Libya; Malawi; Malaysia; Mali; Mauritania; Mauritius; Mexico; Morocco; Netherland-Antilles; Netherlands; New-Zealand; Niger; Nigeria; Oman; Philippines; Portugal; Puerto-Rico; Qatar; Republic-Of-Yemen; Saudi-Arabia; Senegal; Seychelles; Sierra-Leone; South-Africa; South-Africa; Spain; Sudan; Surinam; Switzerland; Syria; Tanzania; Thailand; Trinidad; Tunia; Uganda; United-Arab-Emirates; Zambia; Zimbabwe)
Ceporex Forte (Portugal)
Ceporexin (Argentina; Germany)
Ceporexine (France)
Cerexin (South-Africa)
Durantel DS (Japan)
Erocetin (Argentina; Costa-Rica; Dominican-Republic; El-Salvador; Guatemala; Honduras; Nicaragua; Panama)
Factagard (India)
Felexin (Hong-Kong; Malaysia)
Fexin (South-Africa)
Ibilex (Australia; New-Zealand; Taiwan; Thailand)
Inphalex (Indonesia)
Ibrexin (Korea)
Kefalex (Finland)
Kefalospes (Greece)
Kefaxin (Greece; Ireland)
Kefexin (Czech-Republic; Finland; Germany; Ireland)
Kefloridina (Spain)
Kefolan (Taiwan)
Keforal (Argentina; Belgium; France; Italy; Netherlands)
Lenocef (South-Africa)
Lonflex (Taiwan)
Madlexin (Indonesia)
Mamalexin (Japan)
Medoxine (Philippines)
Neokef (Malaysia)
Novolexin (Canada)
Nufex (India)
Oracef (Bulgaria; Czech-Republic; Germany)
Oriphex (Benin; Burkina-Faso; Ethiopia; Gambia; Ghana; Guinea; Ivory-Coast; Kenya; Liberia; Malawi; Mali; Mauritania; Mauritius; Morocco; Niger; Nigeria; Senegal; Seychelles; Sierra-Leone; South-Africa; Sudan; Tanzania; Tunia; Uganda; Zambia; Zimbabwe)
Ospexin (Austria; Bahrain; Benin; Bulgaria; Burkina-Faso; Costa-Rica; Cyprus; Czech-Republic; Dominican-Republic; Egypt; El-Salvador; Ethiopia; Gambia; Ghana; Guatemala; Guinea; Honduras; Hong-Kong; Indonesia; Iran; Iraq; Israel; Ivory-Coast; Jordan; Kenya; Kuwait; Lebanon; Liberia; Libya; Malawi; Malaysia; Mali; Mauritania; Mauritius; Morocco; Nicaragua; Niger; Nigeria; Oman; Panama; Qatar; Republic-Of-Yemen; Saudi-Arabia; Senegal; Seychelles; Sierra-Leone; South-Africa; Sudan; Syria; Taiwan; Tanzania; Tunia; Uganda; United-Arab-Emirates; Zambia; Zimbabwe)
Palitrex (Bahrain; Cyprus; Ecuador; Egypt; Indonesia; Iran; Iraq; Israel; Jordan; Kuwait; Lebanon; Libya; Oman; Peru; Qatar; Republic-Of-Yemen; Saudi-Arabia; Syria; United-Arab-Emirates)
Pectril (Philippines)
Pyassan (Hungary)
Refosporen (Argentina)
Relaxin (Philippines)
Roceph (India)
Roceph Distab (India)
Sanaxin (Austria)
Septilisin (Argentina)
Sepexin (India)
Servispor (Malaysia; Taiwan)
Sialexin (Thailand)
Sinthecillin (Greece)
Sporicef (Thailand)
Sporidex (Bahrain; Cyprus; Egypt; India; Iran; Iraq; Israel; Jordan; Kuwait; Lebanon; Libya; Oman; Qatar; Republic-Of-Yemen; Saudi-Arabia; Syria; United-Arab-Emirates)
Syncle (Japan)
Tepaxin (Indonesia)
Tokiolexin (Japan)
Uphalexin (Malaysia)
Voxxim (Philippines)
Zozarine (Hong-Kong)

COST OF THERAPY: $43.54 (Skin Infections; Keflex Capsule; 500 mg; 2/day; 7 days)





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