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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (C's) » Colfosceril Palmitate, Cetyl Alcohol, Tyloxapol (Suspension)


EXOSURF NEONATAL (colfosceril palmitate, cetyl alcohol, tyloxapol) for Intratracheal Suspension is a protein-free synthetic lung surfactant stored under vacuum as a sterile lyophilized powder. EXOSURF NEONATAL is reconstituted with preservative-free Sterile Water for Injection prior to administration by intratracheal instillation. Each 10-mL vial contains 108 mg colfosceril palmitate, commonly known as dipalmitoylphosphatidylcholine (DPPC), 12 mg cetyl alcohol, 8 mg tyloxapol, and 47 mg sodium chloride. Sodium hydroxide or hydrochloric acid may have been added to adjust pH. When reconstituted with 8 mL Sterile Water for Injection, the EXOSURF NEONATAL suspension contains 13.5 mg/mL colfosceril palmitate, 1.5 mg/mL cetyl alcohol, and 1 mg/mL tyloxapol in 0.1 N NaCl. The suspension appears milky white with a pH of 5 to 7 and an osmolality of 185 mOsm/kg.

The chemical names of the components of EXOSURF NEONATAL are as follows:

Colfosceril Palmitate

(R)-4-hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxohexadecyl)oxy]-3,5,9-trioxa-4-phosphapentacosan-1-aminium hydroxide inner salt,4-oxide

Cetyl Alcohol

The molecular formula is CH3(CH2)14CH2OH.


4-(1,1,3,3-tetramethylbutyl)phenol polymer with formaldehyde and oxirane

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