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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (D's) » Diltiazem



DESCRIPTION

Diltiazem HCl is a calcium ion influx inhibitor (slow channel blocker or calcium antagonist). Chemically, diltiazem HCL is 1,5-benzothiazepin-4(5H)one, 3- (acetyloxy)-5-[2-( dimethylamino) ethyl]-2, 3-dihydro-2-(4-methoxyphenyl)-, monohydrochloride, (+)-cis-.

Diltiazem hydrochloride is a white to off-white crystalline powder with a bitter taste. It is soluble in water, methanol, and chloroform. It has a molecular weight of 450.98.

Cardizem Direct Compression Tablets: Each tablet contains 30 mg, 60 mg, 90 mg, or 120 mg diltiazem hydrochloride. Also contains: D&C yellow #10 aluminum lake, FD&C yellow #6 aluminum lake (60 mg and 120 mg), or FD&C blue #1 aluminum lake (30 mg and 90 mg), hydroxypropyl methylcellulose, lactose, magnesium stearate, methylparaben, microcrystalline cellulose, silicon dioxide, and other ingredients.

For oral administration.

Cardizem CD Capsules: Cardizem CD is formulated as a once-a-day extended release capsule containing either 120 mg, 180 mg, 240 mg, or 300 mg diltiazem hydrochloride. Also contains: Black iron oxide, ethylcellulose, FD&C blue #1, fumaric acid, gelatin-NF, sucrose, starch, talc, titanium dioxide, white wax and other ingredients.

For oral administration.

Cardizem SR Capsules: Each capsule contains either 60 mg, 90 mg, or 120 mg diltiazem hydrochloride. Also contains: D&C yellow #10, FD&C blue #1, FD&C red #40, FD&C yellow #6, fumaric acid, povidone, starch, sucrose, talc, titanium dioxide, and other ingredients.

For oral administration.

Cardizem Injectable: Cardizem Injectable is a clear, colorless, sterile, nonpyrogenic solution. It has a pH range of 3.7 to 4.1.

Cardizem injectable is for direct intravenous bolus injection and continuous intravenous infusion. 25-mg, 5-ml vial: Each sterile vial contains 25 mg diltiazem hydrochloride, 3.75 mg citric acid USP, 3.25 mg sodium citrate dihydrate, 357 mg sorbitol solution, and water for injection up to 5 ml. Sodium hydroxide or hydrochloric acid is used for pH adjustment. 50-mg, 10-ml vial: Each sterile vial contains 50 mg diltiazem hydrochloride, 7.5 mg citric acid USP, 6.5 mg sodium citrate dihydrate, 714 mg sorbitol solution, and water for injection up to 10 ml. Sodium hydroxide or hydrochloric acid is used for pH adjustment.

Cardizem Lyo-Ject Syringe: Cardizem Lyo-Ject Syringe after reconstitution contains a clear, colorless, sterile nonpyrogenic solution. It has a pH range of 4.0 to 7.0.

Cardizem Lyo-Ject Syringe after reconstitution is for direct intravenous bolus injection and continuous intravenous infusion.

Cardizem Lyo-Ject Syringe 25-mg syringe is available in a dual chamber, disposable syringe. Chamber 1 contains lyophilized powder comprised of diltiazem hydrochloride 25 mg and mannitol 37.5 mg. Chamber 2 contains sterile diluent composed of 5 ml water for injection with 0.5% benzyl alcohol NF, and 0.6% sodium chloride USP.

Cardizem Monovial: Cardizem Monovial, after reconstitution in an infusion bag, produces a clear, colorless, sterile, nonpyrogenic solution.

Cardizem Monovial for continuous intravenous infusion is available in a glass vial with transfer needle set. The vial contains lyophilized powder comprised of diltiazem hydrochloride 100 mg and mannitol 75 mg.

CATEGORIES, BRAND NAMES

CATEGORIES: Angina, chronic stable; Angina, variant; Fibrillation, atrial; Flutter, atrial; Hypertension, essential; Tachycardia, paroxysmal supraventricular; Pregnancy Category C; FDA Approved 1982 Nov; Top 200 Drugs

FDA Drug Classes: Antianginals; Antiarrhythmics; Antihypertensives; Calcium Channel Blockers; Coronary Vasodilators

BRAND NAMES:

BRAND NAMES: Adizem-CD; Altiazem; Altiazem Retard; Altiazem RR; Angiotrofin; Angiotrofin Retard; Angizem; Angoral; Anzem; Apo-diltiazem; Auscard; Bi-Tildiem; Calcicard; Calnurs; Cardcal; Cardil; Cardil Retard; Cardiosta LP; Cardizem; Cardizem CD; Cardizem Retard; Carex; Cartia XT; Cirilen; Cirilen AP; Clarute; Coras; Dazil; Deltazem; Deltazen; Diatal; Dilacor XR; Diladel; Dilatam; Dilatam 120; Dilatame; Dilcard; Dilcardia; Dilcor; Dilem; Dilfar; Dilgard; Dilren; Dilrene; Dilso; Diltahexal; Diltam; Diltan; Diltan SR; Diltelan; Diltiamax; Diltiasyn; Diltikor; Diltime; Dilzem; Dilzem Retard; Dilzem RR; Dilzem SR; Dilzene; Dilzereal 90 Retard; Dilzicardin; Dinisor; Dinisor Retard; Dodexen; Dodexen A.P.; DTM; Dyalac; Gadoserin; Helsibon; Herben; Herbesser; Herbesser 60; Herbesser 90 SR; Herbesser 180 SR; Hesor; Iski; Iski-90 SR; Kaizem CD; Lacerol; Levozem; Lytelsen; Masdil; Miocardie; Myonil; Myonil Retard; Pazeadin; Presoken; Tazem; Tiadil; Tiazac; Tilazem; Tilazem 90; Tildiem; Tildiem CR; Tildiem LA; Tildiem Retard; Zildem; Zilden; Ziruvate
(Foreign Brand names outside U.S. in italics)

FOREIGN BRAND AVAILABILITY:
Adizem-CD (Israel)
Altiazem (Bulgaria; Hong-Kong; Italy)
Altiazem Retard (Italy)
Altiazem RR (Russia)
Angiotrofin (Colombia; Mexico)
Angiotrofin Retard (Costa-Rica; Dominican-Republic; El-Salvador; Guatemala; Honduras; Mexico; Nicaragua; Panama)
Angizem (Italy; Thailand)
Angoral (Colombia)
Anzem (South-Africa)
Apo-diltiazem (New-Zealand)
Auscard (Australia)
Bi-Tildiem (France)
Calcicard (England)
Calnurs (Japan)
Cardcal (Australia)
Cardil (Bulgaria; Denmark; Malaysia; Russia; Taiwan)
Cardil Retard (Greece)
Cardiosta LP (France)
Cardizem CD (Australia; New-Zealand)
Cardizem Retard (Denmark; Finland; Sweden)
Carex (Argentina)
Cirilen (Ecuador)
Cirilen AP (Ecuador)
Coras (Australia; New-Zealand)
Dazil (Bahrain; Cyprus; Egypt; Iran; Iraq; Israel; Jordan; Kuwait; Lebanon; Libya; Oman; Qatar; Republic-of-Yemen; Saudi-Arabia; Syria; United-Arab-Emirates)
Deltazem (Korea)
Deltazen (France)
Diatal (South-Africa)
Diladel (Italy)
Dilatam (Israel; Philippines; South-Africa; Thailand)
Dilatam 120 (Israel)
Dilatame (Austria)
Dilcard (New-Zealand)
Dilcardia (Benin; Burkina-Faso; Ethiopia; Gambia; Ghana; Guinea; India; Ivory-Coast; Kenya; Liberia; Malawi; Mali; Mauritania; Mauritius; Morocco; Niger; Nigeria; Senegal; Seychelles; Sierra-Leone; South-Africa; Sudan; Tanzania; Tunia; Uganda; Zambia; Zimbabwe)
Dilcor (Denmark)
Dilem (Hong-Kong; Thailand)
Dilfar (Portugal)
Dilgard (Benin; Burkina-Faso; Ethiopia; Gambia; Ghana; Guinea; Ivory-Coast; Kenya; Liberia; Malawi; Mali; Mauritania; Mauritius; Morocco; Niger; Nigeria; Senegal; Seychelles; Sierra-Leone; Sudan; Tanzania; Tunia; Uganda; Zambia; Zimbabwe)
Dilren (Russia)
Dilrene (Czech-Republic; France; Hungary)
Dilso (Indonesia)
Diltahexal (Australia; Germany)
Diltam (Ireland)
Diltan (Bahamas; Barbados; Belize; Bermuda; Curacao; Guyana; Jamaica; Netherland-Antilles; Puerto-Rico; Surinam; Trinidad)
Diltan SR (Bahrain; Cyprus; Egypt; Iran; Iraq; Israel; Jordan; Kuwait; Lebanon; Libya; Oman; Qatar; Republic-of-Yemen; Saudi-Arabia; Syria; United-Arab-Emirates)
Diltelan (Korea; Taiwan)
Diltiamax (Australia)
Diltiasyn (Colombia)
Diltikor (Indonesia)
Diltime (Benin; Burkina-Faso; Ethiopia; Gambia; Ghana; Guinea; Ivory-Coast; Kenya; Liberia; Malawi; Mali; Mauritania; Mauritius; Morocco; Niger; Nigeria; Senegal; Seychelles; Sierra-Leone; South-Africa; Sudan; Tanzania; Tunia; Uganda; Zambia; Zimbabwe)
Dilzem (Australia; Austria; Bahamas; Bahrain; Barbados; Belize; Bermuda; Bulgaria; Curacao; Cyprus; Czech-Republic; Egypt; Finland; Germany; Guyana; Hungary; India; Iran; Iraq; Israel; Jamaica; Jordan; Kuwait; Lebanon; Libya; Netherland-Antilles; New-Zealand; Oman; Philippines; Poland; Puerto-Rico; Qatar; Republic-of-Yemen; Russia; Saudi-Arabia; Surinam; Switzerland; Syria; Trinidad; United-Arab-Emirates)
Dilzem Retard (Austria; Bahrain; Bulgaria; Cyprus; Czech-Republic; Egypt; Germany; Iran; Iraq; Israel; Jordan; Kuwait; Lebanon; Libya; Oman; Qatar; Republic-of-Yemen; Saudi-Arabia; Syria; United-Arab-Emirates)
Dilzem RR (Switzerland)
Dilzem SR (England; New-Zealand)
Dilzene (Italy)
Dilzereal 90 Retard (Germany)
Dilzicardin (Germany)
Dinisor (Spain)
Dinisor Retard (Spain)
Dodexen (Peru)
Dodexen A.P. (Peru)
DTM (India)
Dyalac (Philippines)
Gadoserin (Japan)
Helsibon (Japan)
Herben (Korea)
Herbesser (Indonesia; Malaysia; Taiwan; Thailand)
Herbesser 60 (Malaysia; Thailand)
Herbesser 90 SR (Hong-Kong; Malaysia; Thailand)
Herbesser 180 SR (Hong-Kong)
Hesor (Taiwan)
Iski (India)
Iski-90 SR (India)
Kaizem CD (India)
Levozem (Israel)
Lytelsen (Japan)
Masdil (Spain)
Miocardie (Taiwan)
Myonil (Denmark)
Myonil Retard (Denmark)
Pazeadin (Japan)
Presoken (Mexico)
Tazem (Taiwan)
Tiadil (Portugal)
Tilazem (Colombia; Ecuador; Mexico; Peru; South-Africa)
Tilazem 90 (South-Africa)
Tildiem (Belgium; England; France; Greece; Hong-Kong; Italy; Malaysia; Netherlands; Switzerland; Thailand)
Tildiem CR (Netherlands)
Tildiem LA (England)
Tildiem Retard (Greece)
Zildem (South-Africa)
Zilden (Philippines)
Ziruvate (Japan)

COST OF THERAPY: $580.35 (Angina; Cardizem Tablet; 30 mg; 3/day; 365 days)





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