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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (D's) » Doxazosin Mesylate



DESCRIPTION

Doxazosin mesylate is a quinazoline compound that is a selective inhibitor of the alpha1 subtype of alpha adrenergic receptors. The chemical name of doxazosin mesylate is 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(1,4-benzodioxan-2-ylcarbonyl) piperazine methanesulfonate. The empirical formula for doxazosin mesylate is C23H25N5O5CH4O3S and the molecular weight is 547.6.

Cardura is freely soluble in dimethylsulfoxide, soluble in dimethylformamide, slightly soluble in methanol, ethanol, and water (0.8% at 25°C), and very slightly soluble in acetone and methylene chloride. Doxazosin mesylate is available as colored tablets for oral use and contains 1 mg (white), 2 mg (yellow), 4 mg (orange) and 8 mg (green) of doxazosin as the free base.

The inactive ingredients for all tablets are: microcrystalline cellulose, lactose, sodium starch glycolate, magnesium stearate and sodium lauryl sulfate. The 2 mg tablet contains FD&C yellow 10 and FD&C yellow 6; the 4 mg tablet contains FD&C yellow 6; the 8 mg tablet contains FD&C blue 10 and FD&C yellow 10.

CATEGORIES, BRAND NAMES

CATEGORIES: Hyperplasia, benign prostatic; Hypertension, essential; Pregnancy Category B; FDA Class 1C ("Little or No Therapeutic Advantage"); FDA Approved 1990 Nov; Top 200 Drugs; WHO Formulary

FDA Drug Classes: Antihypertensives

BRAND NAMES:

BRAND NAMES: Alfadil; Cardenalin; Cardoral; Cardoxan; Cardular; Cardular PP; Cardular Uro; Cardura; Carduran; Dedralen; Diblocin; Diblocin PP; Diblocin Uro; Doxaben; Kaltensif; Supressin
(Foreign Brand names outside U.S. in italics)

FOREIGN BRAND AVAILABILITY:
Alfadil (Sweden)
Cardenalin (Japan)
Cardoral (Israel)
Cardoxan (New-Zealand)
Cardular (Germany)
Cardular PP (Germany)
Cardular Uro (Germany)
Carduran (Australia; Colombia; Denmark; Norway; Philippines; Spain)
Dedralen (Italy)
Diblocin (Germany)
Diblocin PP (Germany)
Diblocin Uro (Germany)
Doxaben (Taiwan)
Kaltensif (Indonesia)
Supressin (Austria)

COST OF THERAPY: $375.95 (Hypertension; Cardura Tablet; 1 mg; 1/day; 365 days)





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