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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (E's) » Efavirenz



DESCRIPTION

SUSTIVA (efavirenz) in combination with other antiretroviral agents is indicated for the treatment of HIV- 1 infection. This indication is based on analyses of plasma HIV- RNA levels and CD4 cell counts in controlled studies of up to 24 weeks in duration. At present, there are no results from controlled trials evaluating long- term suppression of HIV- RNA with SUSTIVA.

 Resistant virus emerges rapidly when non- nucleoside reverse transcriptase inhibitors (NNRTIs) are administered as monotherapy. Therefore, SUSTIVA must not be used as a single agent to treat HIV or added on as a sole agent to a failing regimen. SUSTIVA therapy should always be initiated in combination with at least one other antiretroviral agent to which the patient has not been previously exposed.


SUSTIVA (efavirenz ) is an HIV-1 specific, non-nucleoside, reverse transcriptase inhibitor (NNRTI).

SUSTIVA is available as capsules for oral administration containing either 50 mg, 100 mg, or 200 mg of efavirenz and the following inactive ingredients: lactose monohydrate, magnesium stearate, sodium lauryl sulfate, and sodium starch glycolate. The capsule shell contains the following inactive ingredients and dyes: gelatin, sodium lauryl sulfate, titanium dioxide and/ or yellow iron oxide. The capsule shells may also contain silicon dioxide. The capsules are printed with ink containing carmine 40 blue, FD& C Blue No. 2 and titanium dioxide.

Efavirenz is chemically described as (S)-6-chloro-4-(cyclopropylethynyl)-1,4-dihydro-4- (trifluoromethyl)-2H-3,1-benzoxazin-2-one. Its empirical formula is C14H9ClF3NO2. Efavirenz is a white to slightly pink crystalline powder with a molecular mass of 315.68. It is practically insoluble in water (< 10 m g/ mL).

 





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