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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (E's) » Etidocaine HCl



DESCRIPTION

Duranest (Etidocaine HCl) Injections are sterile aqueous solutions that contain a local anesthetic agent and are administered parenterally by injection. See INDICATIONS AND USAGE for specific uses. The specific quantitative composition of each available solution is shown in Table 1.

Duranest Injections contain Etidocaine HCl, which is chemically designated as butanamide, N-(2,6-dimethylphenyl)-2-(ethylpropylamine)-, monohydrochloride and Epinephrine which is (-)-3, 4-Dihydroxy-a-[(methylamino) methyl] benzyl alcohol.

The PKa of etidocaine (7.74) is similar to that of lidocaine (7.86). However, etidocaine possesses a greater degree of lipid solubility and protein binding capacity than does lidocaine. Duranest Injections are sterile and, except for the 1.5% concentration, are available with or without epinephrine 1:200,000. Single dose containers of Duranest Injection without epinephrine may be reautoclaved it necessary.

See Table 1 for composition of available injections.

Table1. Composition of Available Injections

Product Identification
Formula

Duranest (etidocaine HCl) Concentration % (mg/mL) 

Epinephrine Dilution (as the bitartrate) (mg/mL)

pH

Sodium chloride (mg/mL)

Single Dose Vials/Dental Cartridge Sodium metabisulfite (mg/mL)

Citric acid (mg/mL)

1.0

(10)

None

4.0- 5.0 

7.1

None

 

1.0

(1.0)

1 :200,000 (0.005 mg/mL)

3.0- 4.5

7.1

0.5

0.2

1.5

(1.5)

1 :200,000 (0.005 mg/mL)

3.0- 4.5

6.2

0.5

0.2


NOTE: pH of all solutions adjusted with sodium hydroxide and/ or hydrochloric acid. Duranest dental cartridges are only available as 1.5% solution with epinephrine 1:200,000. Filled under nitrogen.





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