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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (F's) » Fosinopril



WARNING

Use In Pregnancy: When used in pregnancy during the second and third trimesters, ACE inhibitors can cause injury and even death to the developing fetus. When pregnancy is detected, fosinopril sodium should be discontinued as soon as possible. See WARNINGS, Fetal/Neonatal Morbidity and Mortality.


DESCRIPTION

Fosinopril sodium is the sodium salt of fosinopril, the ester prodrug of an angiotensin converting enzyme (ACE) inhibitor, fosinoprilat. It contains a phosphinate group capable of specific binding to the active site of angiotensin converting enzyme. Fosinopril Sodium is Designated Chemically as : L-proline, 4-cyclohexyl-1-[[[2-methyl-1-(1-oxopropoxy) propoxyl](4-phenylbutyl) phosphinyl]acetyl]-,sodium salt, trans-.

Fosinopril sodium is a white to off-white crystalline powder. It is soluble in water (100 mg/ml), methanol, and ethanol and slightly soluble in hexane.

Its empiric formula is C30H45NNaO7P, and its molecular weight is 585.65.

Monopril is available for oral administration as 10 mg, 20 mg and 40 mg tablets. Inactive ingredients include: lactose, microcrystalline cellulose, crospovidone, povidone, and sodium stearyl fumarate.

CATEGORIES, BRAND NAMES

CATEGORIES: Hypertension, essential; Pregnancy Category D; FDA Class 1C ("Little or No Therapeutic Advantage"); FDA Approved 1991 May; Top 200 Drugs

FDA Drug Classes: Ace Inhibitors; Antihypertensives

BRAND NAMES:

BRAND NAMES: Acenor-M; BPnorm; Dynacil; Fosinil; Fosinorm; Fosipres; Fositen; Fositens; Fozitec; Monopril; Sapril; Staril; Vasopril
(Foreign Brand names outside U.S. in italics)

FOREIGN BRAND AVAILABILITY:
Acenor-M (Indonesia)
BPnorm (Philippines)
Dynacil (Germany)
Fosinil (Belgium)
Fosinorm (Germany)
Fosipres (Italy)
Fositen (Portugal; Switzerland)
Fositens (Austria; Bahrain; Cyprus; Egypt; Iran; Iraq; Israel; Jordan; Kuwait; Lebanon; Libya; Oman; Qatar; Republic-of-Yemen; Saudi-Arabia; Spain; Syria; United-Arab-Emirates)
Fozitec (France)
Staril (England)
Vasopril (Israel)

COST OF THERAPY: $339.45 (Hypertension; Monopril Tablet; 10 mg; 1/day; 365 days)





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