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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (G's) » Glimepiride


Glimepiride tablets are an oral blood-glucose-lowering drug of the sulfonylurea class. Glimepiride is a white to yellowish-white, crystalline, odorless to practically odorless powder formulated into tablets of 1-mg, 2-mg, and 4-mg strengths for oral administration. Amaryl tablets contain the active ingredient glimepiride and the following inactive ingredients: lactose (hydrous), sodium starch glycolate, povidone, microcrystalline cellulose, and magnesium stearate. In addition, Amaryl 1-mg tablets contain ferric oxide red, Amaryl 2-mg tablets contain ferric oxide yellow and FD&C blue #2 aluminum lake, and Amaryl 4-mg tablets contain FD&C blue #2 aluminum lake.

Chemically, glimepiride is identified as 1-[[p-[2-(3-ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido) ethyl]phenyl]sulfonyl]-3-(trans-4-methylcyclohexyl)urea.

The Molecular Formula for Glimepiride is: C24H34N4O5S.

The molecular weight is 490.62.

Glimepiride is practically insoluble in water.


CATEGORIES: Diabetes mellitus; FDA Class 1S ("Standard Review"); FDA Approved 1995 Nov; Pregnancy Category C; Top 200 Drugs

FDA Drug Classes: Blood Glucose Regulators



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