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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (G's) » Granisetron


Kytril (granisetron hydrochloride) is an antinauseant and antiemetic agent. Chemically it is endo-N-(9-methyl-9-azabicyclo [3.3.1] non-3-yl)-1-methyl-1H-indazole-3-carboxamide hydrochloride with a molecular weight of 348.9 (312.4 free base). Its empirical formula is C18H24N4O·HCl.

Granisetron hydrochloride is a white to off-white solid that is readily soluble in water and normal saline at 20°C. Granisetron HCl injection is a clear, colorless, sterile, nonpyrogenic, aqueous solution for intravenous administration.

Each 1 ml of preservative-free aqueous solution contains 1.12 mg granisetron hydrochloride equivalent to granisetron, 1.0 mg and sodium chloride, 9.0 mg. The solution's pH ranges from 4.7 to 7.3.

Tablets for Oral Administration: Each white, triangular, biconvex, film-coated Kytril Tablet contains 1.12 mg granisetron hydrochloride equivalent to granisetron, 1 mg. Inactive ingredients are: hydroxypropyl methylcellulose, lactose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80, sodium starch glycolate and titanium dioxide.


CATEGORIES: Nausea And Vomiting; Nausea and Vomiting; Vomiting; FDA Class 1S (Standard Review); FDA Approved 1993 Dec; Pregnancy Category B

FDA Drug Class: Antiemetics; Vertigo/Motion Sickness/Vomiting

BRAND NAMES: Kevatril; Kytril
(Foreign brand names outside U.S. in italics)

COST OF THERAPY: $177.40 (Nausea; Solution; 1 mg/ml; 1/day; 1 days)

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