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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (H's) » Heparin



DESCRIPTION

HEPARIN SODIUM INJECTION,USP

Heparin is a heterogeneous group of straight-chain anionic mucopolysaccharides, called glycosaminoglycans having anticoagulant properties. Although others may be present, the main sugars occurring in heparin are:

      (1) a-L-iduronic acid 2-sulfate,
      (2) 2-deoxy-2-sulfamino-a-D-glucose 6-sulfate,
      (3) b-D-glucuronic acid,
      (4) 2-acetamido-2-deoxy-a-D-glucose, and
      (5) a-L- iduronic acid.

These sugars are present in decreasing amounts, usually in the order (2) > (1) > (4) > (3) > (5), and are joined by glycosidic linkages, forming polymers of varying sizes. Heparin is strongly acidic because of its content of covalently linked sulfate and carboxylic acid groups. In heparin sodium, the acidic protons of the sulfate units are partially replaced by sodium ions.

Heparin Sodium Injection, USP is a sterile solution of heparin sodium derived from porcine intestinal mucosa, standardized for anticoagulant activity, in water for injection. It is to be administered by intravenous or deep subcutaneous route. The potency is determined by a biological assay using a USP reference standard based on units of heparin activity per milligram.

Heparin Sodium Injection, USP (porcine) is available as follows:

Each 1,000 Units/mL contains: 1,000 USP Heparin Units (porcine); 9 mg sodium chloride; Water for Injection q.s. Hydrochloric acid and/or sodium hydroxide may have been added for pH adjustment (5.0-7.5).

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