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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (H's) » Hydrocortisone; Neomycin; Polymyxin B


Hydrocortisone acetate; neomycin sulfate; polymyxin B sulfate is a topical antibacterial cream and a sterile antibacterial and anti-inflammatory otic solution.

Polymyxin B sulfate is the sulfate salt of polymyxin B1 and B2, which are produced by the growth of Bacillus polymyxa (Prazmowski) Migula (Fam. Bacillaceae). It has a potency of not less than 6000 polymyxin B units per mg, calculated on an anhydrous basis.

Cortisporin Cream: Neomycin sulfate is the sulfate salt of neomycin B and C, which are produced by the growth of Streptomyces fradiae Waksman (Fam. Streptomycetaceae). It has the potency equivalent of not less than 600 mcg of neomycin standard per mg, calculated on an anhydrous basis.

Hydrocortisone acetate is the acetate ester of hydrocortisone, an anti-inflammatory hormone. Its chemical name is 21-(acetyloxy)-11b,17-dihydroxypregn-4-ene-3,20-dione. The base is a smooth vanishing cream with a pH of approximately 5.0.

Cortisporin Otic Solution: The otic solution contains hydrocortisone, 11b,17,21-trihydroxypregn-4-ene-3,20-dione, an anti-inflammatory hormone.

Each Gram of Cortisporin Cream Contains: Neomycin sulfate equivalent to 3.5 mg neomycin base, polymyxin B sulfate equivalent to 10,000 polymyxin B units, and hydrocortisone acetate 5 mg (0.5%). The inactive ingredients are liquid petrolatum, white petrolatum, propylene glycol, polyoxyethylene polyoxypropylene compound, emulsifying wax, purified water, and 0.25% methylparaben added as a preservative. Sodium hydroxide or sulfuric acid may be added to adjust pH.

Each ml of Cortisporin Otic Solution Contains: Neomycin sulfate equivalent to 3.5 mg neomycin base, polymyxin B sulfate equivalent to 10,000 polymyxin B units, and hydrocortisone 10 mg (1%). The vehicle contains potassium metabisulfate 0.1% (added as a preservative) and the inactive ingredients cupric sulfate, glycerin, hydrochloric acid, propylene glycol, and water for injection.

See also Cortisporin topical ointment, Bacitracin Zinc; Hydrocortisone Acetate; Neomycin B Sulfate; Polymyxin B Sulfate.


CATEGORIES: Dermatosis, corticosteroid responsive; Pregnancy Category C; FDA Approved 1985 Aug

FDA Drug Classes: Topical Anti-Infectives; Topical Steroids


BRAND NAMES: Cortisporin; Cortisporin Otico; Neosporin-H Ear; Otosporin
(Foreign Brand names outside U.S. in italics)

Cortisporin Otico (Mexico)
Neosporin-H Ear (India)
Otosporin (Austria; Bahrain; Belgium; Benin; Burkina-Faso; Cyprus; Czech-Republic; Egypt; England; Ethiopia; Gambia; Germany; Ghana; Guinea; Hong-Kong; Hungary; Indonesia; Iran; Iraq; Ireland; Israel; Ivory-Coast; Jordan; Kenya; Kuwait; Lebanon; Liberia; Libya; Malawi; Malaysia; Mali; Mauritania; Mauritius; Morocco; Netherlands; Niger; Nigeria; Oman; Portugal; Qatar; Republic-Of-Yemen; Saudi-Arabia; Senegal; Seychelles; Sierra-Leone; South-Africa; Spain; Sudan; Switzerland; Syria; Taiwan; Tanzania; Thailand; Tunia; Uganda; United-Arab-Emirates; Zambia; Zimbabwe)

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