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You are here: Home » Products Listed by Brand » McKesson Products » Drug Reference (A's) » Alosetron Hydrochloride


The active ingredient in LOTRONEX Tablets is alosetron hydrochloride (HCl), a potent and selective antagonist of the serotonin 5-HT3 receptor type. Chemically, alosetron is designated as 2,3,4,5-tetrahydro-5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-1H-pyrido[4,3-b]indol-1-one, monohydrochloride. Alosetron is achiral and has the empirical formula: C17H18N4O HCl, representing a molecular weight of 330.8. Alosetron is a white to beige solid that has a solubility of 61 mg/mL in water, 42 mg/mL in 0.1 M hydrochloric acid, 0.3 mg/mL in pH 6 phosphate buffer, and <0.1 mg/ mL in pH 8 phosphate buffer.

LOTRONEX Tablets for oral administration contain 1.124 mg alosetron HCl equivalent to 1 mg of alosetron. Each tablet also contains the inactive ingredients, lactose (anhydrous), magnesium stearate, microcrystalline cellulose, and pregelatinized starch. The blue film-coat contains hydroxypropyl methylcellulose, titanium dioxide, triacetin, and indigo carmine.

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