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You are here: Home » Products Listed by Brand » McKesson Products » Drug Reference (A's) » Amoxicillin Clavulanate


Augmentin is an oral antibacterial combination consisting of the semisynthetic antibiotic amoxicillin and the b-lactamase inhibitor, clavulanate potassium (the potassium salt of clavulanic acid). Amoxicillin is an analog of ampicillin, derived from the basic penicillin nucleus, 6-aminopenicillanic acid. The amoxicillin molecular formula is C16H19N3O5S·3H2O and the molecular weight is 419.46. Chemically, amoxicillin is (2S, 5R, 6R)-6-[(R)-(-)-2-Amino-2-(p-hydroxyphenyl)acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid trihydrate.

Clavulanic acid is produced by the fermentation of Streptomyces clavuligerus. It is a b-lactam structurally related to the penicillins and possesses the ability to inactivate a wide variety of b-lactamases by blocking the active sites of these enzymes. Clavulanic acid is particularly active against the clinically important plasmid mediated b-lactamases frequently responsible for transferred drug resistance to penicillins and cephalosporins. The clavulanate potassium molecular formula is C8H8KNO5 and the molecular weight is 237.25. Chemically clavulanate potassium is potassium (Z)-(2R,5R )-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]-heptane-2-carboxylate.

Each Augmentin tablet contains 0.63 mEq potassium.

Each 125 mg chewable tablet and each 5 ml of reconstituted Augmentin 125 mg/5 ml oral suspension contains 0.16 mEq potassium. Each 250 mg chewable tablet and each 5 ml of reconstituted Augmentin 250 mg/5 ml oral suspension contains 0.32 mEq potassium. Each 200 mg chewable tablet and each 5 ml of reconstituted Augmentin 200 mg/5 ml oral suspension contains 0.14 mEq potassium. Each 400 mg chewable tablet and each 5 ml of reconstituted Augmentin 400 mg/5 ml oral suspension contains 0.29 mEq of potassium.

Inactive Ingredients

Powder for Oral Suspension: Colloidal silicon dioxide, flavorings (see HOW SUPPLIED), succinic acid, xanthan gum, and one or more of the following: aspartame, hydroxypropyl methylcellulose, mannitol, silica gel, silicon dioxide and sodium saccharin.

Chewable Tablets: Colloidal silicon dioxide, flavorings (see HOW SUPPLIED), magnesium stearate, mannitol and one or more of the following: aspartame, D&C yellow no. 10, FD&C red no. 40, glycine, sodium saccharin and succinic acid.

(For additional information concerning aspartame see PRECAUTIONS, Information for the Patient.)

Tablets: Colloidal silicon dioxide, hydroxypropyl methylcellulose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, sodium starch glycolate and titanium dioxide.


CATEGORIES: Infection, ear, middle; Infection, respiratory, lower; Infection, sinus; Infection, skin and skin structures; Infection, urinary tract; Pregnancy Category B; FDA Approved 1984 Aug; Top 200 Drugs

FDA Drug Classes: Penicillins


BRAND NAMES: Amocla; Amoclan; Amoclav; Amoran; Amoxsiklav; Ancla; Augmentan; Augmentin; Augmentine; Auspilic; Clamentin; Clamobit; Clamonex; Clamoxyl; Clavinex; Clavoxilin Plus; Clavulin; Clavamox; Clavumox; Eumetinex; Kmoxilin; Viaclav; Xiclav
(Foreign Brand names outside U.S. in italics)

Amocla (Korea)
Amoxsiklav (Thailand)
Ancla (Indonesia)
Augmentan (Germany)
Augmentine (Spain)
Auspilic (Indonesia)
Clamobit (Indonesia)
Clamoxyl (Australia)
Clavinex (Chile)
Clavoxilin Plus (Peru)
Clavulin (Canada; Colombia; Costa-Rica; Dominican-Republic; El-Salvador; Guatemala; Honduras; Nicaragua; Panama)
Clavamox (Germany; India; Indonesia)
Clavumox (Peru)
Eumetinex (Mexico)
Viaclav (Indonesia)
Xiclav (Indonesia)

COST OF THERAPY: $156.98 (Respiratory Infections; Augmentin Tablet; 500 mg;125 mg; 3/day/day; 14 days)

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