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You are here: Home » Products Listed by Brand » McKesson Products » Drug Reference (A's) » Amoxicillin Clavulanate



DESCRIPTION

Augmentin is an oral antibacterial combination consisting of the semisynthetic antibiotic amoxicillin and the b-lactamase inhibitor, clavulanate potassium (the potassium salt of clavulanic acid). Amoxicillin is an analog of ampicillin, derived from the basic penicillin nucleus, 6-aminopenicillanic acid. The amoxicillin molecular formula is C16H19N3O5S·3H2O and the molecular weight is 419.46. Chemically, amoxicillin is (2S, 5R, 6R)-6-[(R)-(-)-2-Amino-2-(p-hydroxyphenyl)acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid trihydrate.

Clavulanic acid is produced by the fermentation of Streptomyces clavuligerus. It is a b-lactam structurally related to the penicillins and possesses the ability to inactivate a wide variety of b-lactamases by blocking the active sites of these enzymes. Clavulanic acid is particularly active against the clinically important plasmid mediated b-lactamases frequently responsible for transferred drug resistance to penicillins and cephalosporins. The clavulanate potassium molecular formula is C8H8KNO5 and the molecular weight is 237.25. Chemically clavulanate potassium is potassium (Z)-(2R,5R )-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]-heptane-2-carboxylate.

Each Augmentin tablet contains 0.63 mEq potassium.

Each 125 mg chewable tablet and each 5 ml of reconstituted Augmentin 125 mg/5 ml oral suspension contains 0.16 mEq potassium. Each 250 mg chewable tablet and each 5 ml of reconstituted Augmentin 250 mg/5 ml oral suspension contains 0.32 mEq potassium. Each 200 mg chewable tablet and each 5 ml of reconstituted Augmentin 200 mg/5 ml oral suspension contains 0.14 mEq potassium. Each 400 mg chewable tablet and each 5 ml of reconstituted Augmentin 400 mg/5 ml oral suspension contains 0.29 mEq of potassium.

Inactive Ingredients

Powder for Oral Suspension: Colloidal silicon dioxide, flavorings (see HOW SUPPLIED), succinic acid, xanthan gum, and one or more of the following: aspartame, hydroxypropyl methylcellulose, mannitol, silica gel, silicon dioxide and sodium saccharin.

Chewable Tablets: Colloidal silicon dioxide, flavorings (see HOW SUPPLIED), magnesium stearate, mannitol and one or more of the following: aspartame, D&C yellow no. 10, FD&C red no. 40, glycine, sodium saccharin and succinic acid.

(For additional information concerning aspartame see PRECAUTIONS, Information for the Patient.)

Tablets: Colloidal silicon dioxide, hydroxypropyl methylcellulose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, sodium starch glycolate and titanium dioxide.

CATEGORIES, BRAND NAMES

CATEGORIES: Infection, ear, middle; Infection, respiratory, lower; Infection, sinus; Infection, skin and skin structures; Infection, urinary tract; Pregnancy Category B; FDA Approved 1984 Aug; Top 200 Drugs

FDA Drug Classes: Penicillins

BRAND NAMES:

BRAND NAMES: Amocla; Amoclan; Amoclav; Amoran; Amoxsiklav; Ancla; Augmentan; Augmentin; Augmentine; Auspilic; Clamentin; Clamobit; Clamonex; Clamoxyl; Clavinex; Clavoxilin Plus; Clavulin; Clavamox; Clavumox; Eumetinex; Kmoxilin; Viaclav; Xiclav
(Foreign Brand names outside U.S. in italics)

FOREIGN BRAND AVAILABILITY:
Amocla (Korea)
Amoxsiklav (Thailand)
Ancla (Indonesia)
Augmentan (Germany)
Augmentine (Spain)
Auspilic (Indonesia)
Clamobit (Indonesia)
Clamoxyl (Australia)
Clavinex (Chile)
Clavoxilin Plus (Peru)
Clavulin (Canada; Colombia; Costa-Rica; Dominican-Republic; El-Salvador; Guatemala; Honduras; Nicaragua; Panama)
Clavamox (Germany; India; Indonesia)
Clavumox (Peru)
Eumetinex (Mexico)
Viaclav (Indonesia)
Xiclav (Indonesia)

COST OF THERAPY: $156.98 (Respiratory Infections; Augmentin Tablet; 500 mg;125 mg; 3/day/day; 14 days)





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