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You are here: Home » Products Listed by Brand » McKesson Products » Drug Reference (A's) » Amphotericin B


This drug should be used primarily for treatment of patients with progressive and potentially life-threatening fungal infections; it should be not be used to treat noninvasive forms of fungal disease such as oral thrush, vaginal candidiasis and esophageal candidiasis in patients with normal neutrophil counts.


FUNGIZONE intravenous (Amphotericin B for Injection) contains amphotericin B, an antifungal polyene antibiotic obtained from a strain of Streptomyces nodosus. Amphotericin B is designated chemically as [1R-( 1R*, 3S*, 5R*, 6R*, 9R*, 11R*, 15S*, 16R*, 17R*, 18S*, 19E, 21E, 23E, 25E, 27E, 29E, 31E, 33R*, 35S *, 36R*, 7S*)]-33-[(3-Amino-3,6-dideoxy-ß-D- mannopyranosyl)-oxy],3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl 13-oxo-14,39- dioxabicyclo[ 33.3.1] nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid.

The chemical formula is C47H73NO17 and the molecular weight is 924.09 Each vial contains a sterile, nonpyrogenic, lyophilized cake (which may partially reduce to powder following manufacture) providing 50 mg amphotericin B and 41 mg sodium desoxycholate with 20.2 mg sodium phosphates as a buffer. Crystalline amphotericin B is insoluble in water; therefore, the antibiotic is solubilized by the addition of sodium desoxycholate to form a mixture which provides a colloidal dispersion for intravenous infusion following reconstitution.

At the time of manufacture the air in the vial is replaced by nitrogen.

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