CASODEX® (bicalutamide) Tablets for oral administration
contain 50 mg of bicalutamide, a nonsteroidal antiandrogen with no other
known endocrine activity. The chemical name is propanamide, N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)
Bicalutamide has a following molecular formaula: C18H14N2O4F4S.
Bicalutamide has a molecular weight of 430.37. The pKa is approximately
12. Bicalutamide is a fine white to off-white powder which is practically
insoluble in water at 37C (5 mg per 1000 mL), slightly soluble in chloroform
and absolute ethanol, sparingly soluble in methanol, and soluble in acetone
CASODEX is a racemate with its antiandrogenic activity being almost exclusively
exhibited by the R-enantiomer of bicalutamide; the S-enantiomer is essentially
The inactive ingredients of CASODEX Tablets are lactose, magnesium stearate,
methylhydroxypropylcellulose, polyethylene glycol, polyvidone, sodium
starch glycollate, and titanium dioxide.