ZEBETA (bisoprolol fumarate) is a synthetic beta1-selective
(cardioselective) adrenoceptor blocking agent. The chemical name for bisoprolol
fumarate is ()-1-[4-[[2-(1-Methylethoxy)ethoxy]methyl]phenoxyl-3-[(1-methylethyl)amino]-2-propanol(E)-2-butenedloate
(2:1) (salt). It possesses an asymmetric carbon atom in its structure
and is provided as a racemic mixture. The S(-) enantiomer is responsible
for most of the beta-blocking activity. Its empirical formula is (C18H31NO4)2
Bisoprolol fumarate has a molecular weight of 766.97. It is a white crystalline
powder which is approximately equally hydrophilic and lipophilic, and
is readily soluble in water, methanol, ethanol, and chloroform.
ZEBETA is available as 5 and 10 mg tablets for oral administration.
Inactive ingredients include: Colloidal Silicon Dioxide, Corn Starch,
Crospovidone, Dibasic Calcium Phosphate, Hydroxypropyl Methylcellulose,
Magnesium Stearate, Microcrystalline Cellulose, Polyethylene Glycol, Polysorbate
80, and Titanium Dioxide. The 5 mg tablets also contain Red and Yellow