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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (B's) » Botulinum Toxin


BOTOX® (Botulinum Toxin Type A) Purified Neurotoxin Complex is a sterile, vacuum-dried form of purified botulinum toxin type A, produced from a culture of the Hall strain of Clostridium botulinum grown in a medium containing N-Z amine and yeast extract. It is purified from the culture solution by a series of acid precipitations to a crystalline complex consisting of the active high molecular weight toxin protein and an associated hemagglutinin protein. The crystalline complex is re-dissolved in a solution containing saline and albumin and sterile filtered (0.2 microns) prior to vacuum-drying. BOTOX® is to be reconstituted with sterile, non-preserved saline prior to intramuscular injection.

Each vial of BOTOX® Purified Neurotoxin Complex contains 100 units (U) of Clostridium botulinum toxin type A, 0.5 milligrams of albumin (human), and 0.9 milligrams of sodium chloride in a sterile, vacuum-dried form without a preservative. One unit (U) corresponds to the calculated median lethal intraperitoneal dose (LD/50) in mice of the reconstituted BOTOX® injected.

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