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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (B's) » Brinzolamide


AZOPTTM (brinzolamide ophthalmic suspension) 1% contains a carbonic anhydrase inhibitor formulated for multidose topical ophthalmic use. Brinzolamide is described chemically as: (R)-(+)-4-Ethylamino-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e]- 1,2-thiazine-6-sulfonamide-1,1-dioxide. Its empirical formula is C12 H21 N3O5 S3.

Brinzolamide has a molecular weight of 383.5 and a melting point of about 131C. It is a white powder, which is insoluble in water. very soluble in methanol and soluble in ethanol.

AZOPT 1 % is supplied as a sterile, aqueous suspension of brinzolamide which has been formulated to be readily suspended and wslow settling, following shaking. It has a pH of approximately 7.5 and an osmolality of 300 mOsm/kg. Each mL of AZOPT 1% contains 10 mg brinzolamide. Inactive ingredients are mannitol, carbomer 974P, tyloxapol, edetate disodium, sodium chloride, hydrochloric acid and/or sodium hydroxide (to adjust pH), and purified water. Benzalkonium chloride 0.01 % is added as a preservative.

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