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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (B's) » Butorphanol Tartrate



DESCRIPTION

Butorphanol tartrate is a synthetically derived opioid agonist-antagonist analgesic of the phenanthrene series. The chemical name is (-)-17-( cyclobutylmethyl) morphinan- 3, 14- diol [S-( R*, R*)] - 2,3 - dihydroxybutanedioate (1: 1) (salt). The molecular formula is C21H29 NO2,C4H6O6, which corresponds to a molecular weight of 477.55.

Butorphanol tartrate is a white crystalline substance. The dose is expressed as the tartrate salt. One milligram of the salt is equivalent to 0.68 mg of the free base. The n-octanol/aqueous buffer partition coefficient of butorphanol is 180:1 at pH 7.5.

STADOL (butorphanol tartrate) Injection, USP, is a sterile, parenteral, aqueous solution of butorphanol tartrate for intravenous or intramuscular administration. In addition to 1 or 2 mg of butorphanol tartrate, each mL of solution contains 3.3 mg of citric acid, 6.4 mg sodium citrate, and 6.4 mg sodium chloride, and 0.1 mg benzethonium chloride (in multiple dose vial only) as a preservative.

STADOL NS (butorphanol tartrate) is an aqueous solution of butorphanol tartrate for administration as a metered spray to the nasal mucosa. Each bottle of STADOL NS contains 2.5 mL of a 10 mg/mL solution of butorphanol tartrate with sodium chloride, citric acid, and benzethonium chloride in purified water with sodium hydroxide and/or hydrochloric acid added to adjust the pH to 5.0. The pump reservoir must be fully primed (see PATIENT INSTRUCTIONS in HOW SUPPLIED) prior to initial use. After initial priming each metered spray delivers an average of 1.0 mg of butorphanol tartrate and the 2.5 mL bottle will deliver an average of 1415 doses of STADOL NS. If not used for 48 hours or longer, the unit must be reprimed (see PATIENT INSTRUCTIONS in HOW SUPPLIED). With intermittent use requiring repriming before each dose, the 2.5 mL bottle will deliver an average of 810 doses of STADOL NS depending on how much repriming is necessary.





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