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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (C's) » Candesartan



WARNING

USE IN PREGNANCY When used in pregnancy during the second and third trimesters drugs that act directly on the renin angiotensin system can cause injury and even death to the developing fetus When pregnancy is detected ATACAND should be discontinued as soon as possible See WARNINGS: Fetal Neonatal Morbidity and Mortality.

DESCRIPTION

ATACAND (candesartan cilexetil) a prodrug is hydrolyzed to candesartan during absorption from the gastrointestinal tract. Candesartan is a selective AT1 subtype angiotensin II receptor antagonist.
Candesartan cilexetil a nonpeptide is chemically described as:

( + ) -1-[[(cyclohexyloxy)carbonyl] oxy]ethyl
2- ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4- yl]methyl]-1H-benzimidazole-7-carboxylate. Its empirical formula is C33H34N6O6.

Candesartan cilexetil is a white to off-white powder with a molecular weight of 610.67. It is practically insoluble in water and sparingly soluble in methanol. Candesartan cilexetil is a racemic mixture containing one chiral center at the cyclohexyloxycarbonyloxy ethyl ester group. Following oral administration candesartan cilexetil undergoes hydrolysis at the ester link to form the active drug candesartan which is achiral.

ATACAND is available for oral use as tablets containing either 4 mg, 8 mg, 16 mg or 32 mg of
candesartan cilexetil and the following inactive ingredients: hydroxypropyl cellulose, polyethylene glycol, lactose, corn starch, carboxymethylcellulose calcium, and magnesium stearate. Ferric oxide reddish brown is added to the 8 mg, 16 mg, and 32 mg tablets as a colorant.





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