DESCRIPTION

Ceftin tablets and Ceftin for oral suspension contain cefuroximine as cefuroximine axetil. Cefuroxime axetil is a semisynthetic, broad-spectrum cephalosporin antibiotic for oral administration.

Chemically, cefuroxime axetil, the 1-(acetyloxy) ethyl ester of cefuroxime, is (RS)-1-hydroxyethyl (6R,7R)-7-[2-(2-furyl)glyoxylamido]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate, 7²-(Z)-(O-methyl-oxime),1 -acetate 3-carbamate. Its molecular formula is C₂₀H₂₂N₄O₁₀S, and it has a molecular weight of 510.48.

Cefuroxime axetil is in the amorphous form.

Ceftin tablets are film-coated and contain the equivalent of 125, 250, or 500 mg of cefuroxime as cefuroxime axetil. Ceftin tablets contain the inactive ingredients colloidal silicon dioxide, croscarmellose sodium, FD&C blue no. 1 (250-and 500-mg tablets only), hydrogenated vegetable oil, hydroxypropyl methylcellulose, methylparaben, microcrystalline cellulose, propylene glycol, propylparaben, sodium benzoate (125-mg tablets only), sodium lauryl sulfate, and titanium dioxide.

Ceftin for oral suspension, when reconstituted with water, provides the equivalent of 125 mg or 250 mg of cefuroxime (as cefuroxime axetil) per 5 ml of suspension. Ceftin powder for oral suspension contains the inactive ingredients povidone K30, stearic acid, sucrose, and tutti-frutti flavoring.

CATEGORIES, BRAND NAMES

CATEGORIES: Bronchitis, acute; Bronchitis, chronic, acute exacerbation; Infection, ear, middle; Infection, gonorrhea; Infection, sexually transmitted; Infection, skin and skin structures; Infection, upper respiratory tract; Infection, urinary tract; Pharyngitis; Tonsillitis; Pregnancy Category B; FDA Approved 1987 Dec; Top 200 Drugs

FDA Drug Classes: Cephalosporins

BRAND NAMES:

BRAND NAMES: Cefuril; Ceftin; Celocid; Cepazine; Cethixim; Elobact; Furoxime; Kalcef; Sharox-500; Zinacef; Zinat; Zinnat; Zoref
(Foreign Brand names outside U.S. in italics)

FOREIGN BRAND AVAILABILITY:
Cefuril (India)
Celocid (Indonesia)
Cepazine (France)
Cethixim (Indonesia)
Elobact (Germany)
Furoxime (Thailand)
Kalcef (Indonesia)
Sharox-500 (Indonesia)
Zinacef (Philippines)
Zinat (Switzerland)
Zinnat (Austria; Bahamas; Bahrain; Barbados; Belgium; Belize; Benin; Bermuda; Burkina-Faso; Colombia; Costa-Rica; Curacao; Cyprus; Czech-Republic; Denmark; Dominican-Republic; Egypt; El-Salvador; England; Ethiopia; Finland; France; Gambia; Germany; Ghana; Guatemala; Guinea; Guyana; Honduras; Hong-Kong; Indonesia; Iran; Iraq; Ireland; Israel; Italy; Ivory-Coast; Jamaica; Jordan; Kenya; Korea; Kuwait; Lebanon; Liberia; Libya; Malawi; Malaysia; Mali; Mauritania; Mauritius; Mexico; Morocco; Netherland-Antilles; Netherlands; New-Zealand; Niger; Nigeria; Oman; Panama; Philippines; Puerto-Rico; Qatar; Republic-of-Yemen; Saudi-Arabia; Senegal; Seychelles; Sierra-Leone; South-Africa; Spain; Sudan; Surinam; Switzerland; Syria; Taiwan; Tanzania; Thailand; Trinidad; Tunia; Uganda; United-Arab-Emirates; Zambia; Zimbabwe)
Zoref (Portugal)

COST OF THERAPY: $208.04 (Respiratory Infections; Ceftin Tablet; 500 mg; 2/day; 14 days)

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