Chlorthalidone is an oral antihypertensive/diuretic. It is a monosulfamyl
diuretic that differs chemically from thiazide diuretics in that a double-ring
system is incorporated in its structure. It is 2-chloro-5(1-hydroxy-3-oxo-1-isoindolinyl)
It has the following molecular formula C14H11C1N2O4S
with a molecular weight of 338.76.
Chlorthalidone is practically insoluble in water, in ether, and in chloroform;
soluble in methanol; slightly soluble in ethanol.
Chlorthalidone tablets are available containing either 25 mg or 50 mg
of chlorthalidone USP and the following inactive ingredients: colloidal
silicon dioxide, microcrystalline cellulose, D&C Yellow #10, sodium starch
glycolate, pregelatinized starch, stearic acid and other inactive ingredients.
The 50 mg tablet also contains FD&C Blue #1.