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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (C's) » Cimetidine



DESCRIPTION

Cimetidine HCl is a histamine H2-receptor antagonist. Chemically it is guanidine, N''- cyano-N-methyl-N¢- [2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]-ethyl]-monohydrochloride.

The molecular formula for cimetidine HCl is C10H16N6S·HCl; this represents a molecular weight of 288.81.

Cimetidine contains an imidazole ring, and is chemically related to histamine. The liquid and injection dosage forms contain cimetidine as the hydrochloride salt.

Cimetidine HCl has a bitter taste and characteristic odor.

Solubility Characteristics: Cimetidine HCl is freely soluble in water, soluble in alcohol, very slightly soluble in chloroform, and practically insoluble in ether.

Oral

Tablets: Each light green, film-coated tablet contains cimetidine as follows: 200 mg-round, imprinted with the product name Tagamet, SKF and 200; 300 mg-round, debossed with the product name Tagamet, SB and 300; 400 mg-oval Tiltab tablets, debossed with the product name Tagamet, SB and 400; 800 mg-oval Tiltab tablets, debossed with the product name Tagamet, SB and 800. Inactive ingredients consist of cellulose, D&C yellow no. 10, FD&C blue No. 2, FD&C red no. 40, FD&C yellow no. 6, hydroxypropyl methylcellulose, iron oxides, magnesium stearate, povidone, propylene glycol, sodium lauryl sulfate, sodium starch glycolate, starch, titanium dioxide and trace amounts of other inactive ingredients.

Oral Solution: Each 5 ml (one teaspoonful) of clear, light orange, mint-peach flavored liquid contains cimetidine HCl equivalent to cimetidine, 300 mg; alcohol, 2.8%. Inactive ingredients consist of FD&C yellow no. 6, flavors, methylparaben, polyoxyethylene polyoxypropylene glycol, propylene glycol, propylparaben, saccharin sodium, sodium chloride, sodium phosphate, sorbitol and water.

Injection

Single-Dose Vials for Intramuscular or Intravenous Administration: Each 2 ml contains, in sterile aqueous solution (pH range 3.8 to 6), cimetidine HCl equivalent to cimetidine, 300 mg; phenol, 10 mg.

Multi-Dose Vials for Intramuscular or Intravenous Administration: 8 ml (300 mg/2 ml): Each 2 ml contains, in sterile aqueous solution (pH range 3.8 to 6), cimetidine HCl equivalent to cimetidine, 300 mg; phenol, 10 mg.

Single-Dose Premixed Plastic Containers for Intravenous Administration: Each 50 ml of sterile aqueous solution (pH range 5 to7) contains cimetidine HCl equivalent to 300 mg cimetidine and 0.45 grams sodium chloride.

No preservative has been added.

The plastic container is fabricated from specially formulated polyvinyl chloride. The amount of water that can permeate from inside the container into the overwrap is insufficient to affect the solution significantly. Solutions in contact with the plastic container can leach out certain of its chemical components in very small amounts within the expiration period, e.g., di 2-ethylhexyl phthalate (DEHP), up to 5 parts per million. However, the safety of the plastic has been confirmed in tests in animals according to the USP biological tests for plastic containers as well as by tissue culture toxicity studies.

ADD-Vantage* Vials for Intravenous Administration: Each 2 ml contains, in sterile aqueous solution (pH range 3.8 to 6), cimetidine HCl equivalent to cimetidine, 300 mg; phenol, 10 mg.

All of the above injection formulations are pyrogen free, and sodium hydroxide is used as an ingredient to adjust the pH.

CATEGORIES, BRAND NAMES

CATEGORIES: Acid/peptic disorder; Adenoma, secretory; Hemorrhage, upper gastrointestinal; Hypersecretory conditions, gastrointestinal; Mastocytosis, systemic; Reflux, gastroesophageal; Ulcer, duodenal; Ulcer, gastric; Zollinger-Ellison syndrome; Pregnancy Category B; FDA Approved 1986 Apr; Top 200 Drugs; WHO Formulary

FDA Drug Classes: Disorders, Acid/Peptic

BRAND NAMES:

BRAND NAMES: Acibilin; Acidown; Aciloc; Aci-Med; Acinil; Altramet; Antil; Apo-Cimetidine; Asaurex; Azucimet; Beamat; Biomag; Brumetidina; Campanex; Cemedin 200; Cemedin 400; Cemedin 800; Cidine; Cigamet; Cignatin; Cimal; Cimebec; Cimbene; Cimedine; Cimehexal; Cimeldine; Cimet; Cimetag; Cimetalgin; Cimetase; Cimetegal; Cimetid; Cimetidin; Cimetidina; Cimetidine; Cimetidine In Sodium Chloride; Cimetigal; Cimetiget; Cimetil; Cimetin; Cimetum; Cimewell; Cimewet; Cimex; Cimulcer; Cinadine; Cinulcus; Cismetin; Citidine; Citius; Ciuk; Ciwidine; Convenal; Corsamet; Cytine; Defense; Dispamet; Duomet; Dyspamet; Edalene; Eureceptor; Fanimet; Fremet; Gastidine; Gastrobitan; Gastrodin; Gawei; Gerucim; H-2; Haldin; Hexamet; Himetin; Histodil; Inesfay; Lenamet; Lock 2; Magicul; Med-Gastramet; Montidin; Neutronorm; Novocimetine; Nulcer; Pallia; Paoweian; Peptol; Piovalen; Powegon; Procimeti; Proctospre; Sanmetidin; Secapine; Shintamet; Siamidine; Silmet; Simalgen; Stogamet; Stomakon; Stomedine; Stomet; Tagagel; Tagamed; Tagamet; Tagamin; Tametin; Timet; Tobymet; Tratol; Ulcedin; Ulcedine; Ulcemet; Ulcerfen; Ulcim; Ulcimet; Ulcinfan; Ulcodina; Ulcomedina; Ulcolind H2; Ulcumet; Ulpax; Ulsikur; Valmagen; Weisdin; Wergen; Xepamet; Zymerol
(Foreign Brand names outside U.S. in italics)

FOREIGN BRAND AVAILABILITY:
Acibilin (Argentina)
Acidown (South-Africa)
Aciloc (Denmark; Sweden)
Aci-Med (South-Africa)
Acinil (Benin; Burkina-Faso; Denmark; Ethiopia; Gambia; Ghana; Guinea; Ivory-Coast; Kenya; Liberia; Malawi; Mali; Mauritania; Mauritius; Morocco; Niger; Nigeria; Senegal; Seychelles; Sierra-Leone; South-Africa; Sudan; Sweden; Tanzania; Tunia; Uganda; Zambia; Zimbabwe)
Altramet (Hong-Kong)
Apo-Cimetidine (Canada; New-Zealand)
Asaurex (Mexico)
Azucimet (Germany)
Biomag (Italy)
Brumetidina (Italy)
Campanex (Greece)
Cemedin 200 (Israel)
Cemedin 400 (Israel)
Cemedin 800 (Israel)
Cidine (Thailand)
Cigamet (Thailand)
Cignatin (Korea)
Cimal (Norway)
Cimbene (Bahamas; Barbados; Belize; Bermuda; Curacao; Guyana; Jamaica; Netherland-Antilles; Puerto-Rico; Surinam; Trinidad)
Cimedine (Bahrain; Cyprus; Egypt; Iran; Iraq; Israel; Jordan; Kuwait; Lebanon; Libya; Oman; Qatar; Republic-Of-Yemen; Saudi-Arabia; Syria; United-Arab-Emirates)
Cimehexal (Germany)
Cimeldine (Ireland)
Cimet (Indonesia; Thailand)
Cimetag (Austria; Israel)
Cimetalgin (Austria)
Cimetase (Mexico)
Cimetid (Norway)
Cimetidin (Bulgaria; Denmark; Germany; Switzerland)
Cimetidina (Colombia; Spain)
Cimetidine (Czech-Republic; India; Netherlands)
Cimetigal (Mexico)
Cimetin (Czech-Republic; Ecuador)
Cimetum (Argentina)
Cimewell (Taiwan)
Cimex (Finland)
Cimulcer (Malaysia; Thailand)
Cinadine (South-Africa)
Cinulcus (Spain)
Cismetin (Korea)
Citidine (Hong-Kong; Korea)
Citius (Bahrain; Cyprus; Egypt; Iran; Iraq; Israel; Jordan; Kuwait; Lebanon; Libya; Oman; Qatar; Republic-Of-Yemen; Saudi-Arabia; Syria; United-Arab-Emirates)
Ciuk (Germany)
Convenal (Colombia)
Corsamet (Indonesia)
Cytine (New-Zealand)
Defense (Taiwan)
Dispamet (Bahrain; Cyprus; Egypt; Iran; Iraq; Israel; Jordan; Kuwait; Lebanon; Libya; Oman; Qatar; Republic-Of-Yemen; Saudi-Arabia; Syria; United-Arab-Emirates)
Duomet (New-Zealand; South-Africa)
Dyspamet (England)
Eureceptor (Italy)
Fanimet (Korea)
Fremet (Spain)
Gastidine (Hong-Kong)
Gastrobitan (Norway)
Gastrodin (Taiwan)
Gawei (Taiwan)
H-2 (Korea)
Haldin (Bahrain; Benin; Burkina-Faso; Cyprus; Egypt; Ethiopia; Gambia; Ghana; Guinea; Iran; Iraq; Israel; Ivory-Coast; Jordan; Kenya; Kuwait; Lebanon; Liberia; Libya; Malawi; Mali; Mauritania; Mauritius; Morocco; Niger; Nigeria; Oman; Qatar; Republic-Of-Yemen; Saudi-Arabia; Senegal; Seychelles; Sierra-Leone; South-Africa; Sudan; Syria; Tanzania; Tunia; Uganda; United-Arab-Emirates; Zambia; Zimbabwe)
Hexamet (South-Africa)
Himetin (Korea)
Histodil (Hungary; Thailand)
Inesfay (Mexico)
Lenamet (South-Africa)
Lock 2 (Benin; Burkina-Faso; Ethiopia; Gambia; Ghana; Guinea; Ivory-Coast; Kenya; Liberia; Malawi; Mali; Mauritania; Mauritius; Morocco; Niger; Nigeria; Senegal; Seychelles; Sierra-Leone; South-Africa; Sudan; Tanzania; Tunia; Uganda; Zambia; Zimbabwe)
Magicul (Australia; New-Zealand)
Med-Gastramet (Thailand)
Montidin (Philippines)
Neutronorm (Austria)
Novocimetine (Canada)
Nulcer (Indonesia)
Pallia (Hong-Kong)
Peptol (Canada)
Piovalen (Greece)
Powegon (Taiwan)
Sanmetidin (Indonesia)
Secapine (South-Africa)
Shintamet (Malaysia)
Siamidine (Thailand)
Stogamet (Taiwan)
Stomakon (Brazil)
Stomedine (France)
Stomet (Italy)
Tametin (Italy)
Timet (Bahrain; Cyprus; Egypt; Iran; Iraq; Israel; Jordan; Kuwait; Lebanon; Libya; Oman; Qatar; Republic-Of-Yemen; Saudi-Arabia; Syria; United-Arab-Emirates)
Tobymet (Indonesia)
Ulcedin (Italy)
Ulcedine (Thailand)
Ulcemet (Ecuador)
Ulcerfen (Argentina)
Ulcim (South-Africa)
Ulcimet (Argentina; Ecuador; Indonesia; Peru)
Ulcodina (Italy)
Ulcomedina (Italy)
Ulcolind H2 (Germany)
Ulcumet (Indonesia)
Ulsikur (Indonesia)
Weisdin (Taiwan)
Xepamet (Malaysia)
Zymerol (Mexico)

COST OF THERAPY: 11.63 (Duodenal Ulcer; Tablet; 800 mg; 1/day; 28 days)





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