LOTRISONE Cream contains a combination of clotrimazole, USP, a synthetic
antifungal agent, and betamethasone
dipropionate, USP, a synthetic
corticosteroid, for dermatologic use. Chemicaliy, clotrimazole
is 1-(a-Chloro, a,
with the empirical formula
C22H17ClN2 and a molecular weight
of 344.8. Clotrimazole is an odorless, white crystalline powder, insoluble
in water and soluble
Betamethasone dipropionate has the chemical
17,21-dipropionate, with the empirical
and a molecular weight of 504.6.
Betamethasone dipropionate is a white to creamy white, odorless crystalline
powder, insoluble in water.
Each gram of LOTRISONE Cream
contains 10.0 mg clotrimazole,
USP and 0.64 mg betamethasone
dipropionate, USP (equivalent to 0.5 mg
betamethasone), in a hydrophilic emollient
cream consisting of purified
water, mineral oil, white petrolatum,
cetearyl alcohol, ceteareth-30,
propylene glycol, sodium phosphate
monobasic, and phosphoric acid; benzyl
alcohol as preservative.
LOTRISONE is a smooth, uniform, white
to off-white cream.