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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (C's) » Clotrimazole and Betamethasone


LOTRISONE Cream contains a combination of clotrimazole, USP, a synthetic antifungal agent, and betamethasone dipropionate, USP, a synthetic corticosteroid, for dermatologic use. Chemicaliy, clotrimazole is 1-(a-Chloro, a, a-diphenylbenzyl) imid-azole, with the empirical formula C22H17ClN2 and a molecular weight of 344.8. Clotrimazole is an odorless, white crystalline powder, insoluble in water and soluble in ethanol.

Betamethasone dipropionate has the chemical name 9-Fluoro-1,16,17,21-trihydroxy-16B-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate, with the empirical formula C28H37FO7 and a molecular weight of 504.6. Betamethasone dipropionate is a white to creamy white, odorless crystalline powder, insoluble in water.

Each gram of LOTRISONE Cream contains 10.0 mg clotrimazole, USP and 0.64 mg betamethasone dipropionate, USP (equivalent to 0.5 mg betamethasone), in a hydrophilic emollient cream consisting of purified water, mineral oil, white petrolatum, cetearyl alcohol, ceteareth-30, propylene glycol, sodium phosphate monobasic, and phosphoric acid; benzyl alcohol as preservative.

LOTRISONE is a smooth, uniform, white to off-white cream.

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