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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (D's) » Diclofenac



DESCRIPTION

Diclofenac, as the sodium or potassium salt, is a benzeneacetic acid derivative, designated chemically as 2-[(2,6-dichlorophenyl)amino] benzeneacetic acid, monosodium or monopotassium salt.

Diclofenac, as the sodium or potassium salt, is a faintly yellowish white to light beige, virtually odorless, slightly hygroscopic crystalline powder. Molecular weights of the sodium and potassium salts are 318.14 and 334.25, respectively. It is freely soluble in methanol, soluble in ethanol, and practically insoluble in chloroform and in dilute acid. Diclofenac sodium is sparingly soluble in water while diclofenac potassium is soluble in water. The noctanol/water partition coefficient is, for both diclofenac salts, 13.4 at pH 7.4 and 1,545 at pH 5.2. Both salts have a single dissociation constant (pKa) of 4.0 + 0.2 at 25° C in water.

Diclofenac potassium is available as Cataflam Immediate-Release Tablets of 50 mg for oral administration.

CATAFLAM Inactive Ingredients: Calcium phosphate, colloidal silicon dioxide, iron oxides, magnesium stearate, microcrystalline cellulose, polyethylene glycol, povidone, sodium starch glycolate, starch, sucrose, talc, titanium dioxide.

Diclofenac sodium is available as VOLTAREN Delayed-Release (enteric-coated) Tablets of 25 mg, 50 mg, and 75 mg for oral administration, and VOLTAREN-XR Extended-Release Tablets of 100 mg.

VOLTAREN Inactive Ingredients: Hydroxypropyl methylcellulose, iron oxide, lactose, magnesium stearate, methacrylic acid copolymer, microcrystalline cellulose, polyethylene glycol, povidone, propylene glycol, sodium hydroxide, sodium starch glycolate, talc, titanium dioxide, D&C Yellow No.10 Aluminum Lake (25-mg tablet only), FD&C Blue No.1 Aluminum Lake (50-mg tablet only).

VOLTAREN-XR Inactive Ingredients: Cetyl alcohol, hydroxypropyl methylcellulose, iron oxide, magnesium stearate, polyethylene glycol, polysorbate, povidone, silicon dioxide, sucrose, talc, titanium dioxide.





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