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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (D's) » Diphenhydramine


Diphenhydramine hydrochloride, is an antihistamine drug having the chemical name 2-(Diphenylmethoxy)-N,N-dimethylethylamine hydrochloride and has the empirical formula C17H21NO·HCl. It occurs as a white, crystalline powder and is freely soluble in water and alcohol and has a molecular weight of 291.82.

Each diphenhydramine HCl capsule contains 25 mg or 50 mg diphenhydramine hydrochloride for oral administration.

Each Benadryl 25-mg capsule also contains lactose, NF and magnesium stearate, NF. The capsule shell and/or band contains D&C red No. 28; FD&C blue No. 1; FD&C red No. 3; FD&C red No. 40; gelatin, NF; colloidal silicon dioxide, NF; and sodium lauryl sulfate, NF.

Each Benadryl 50-mg capsule also contains confectioner's sugar, NF and talc, USP. The capsule shell and/or band contains FD&C blue No. 1; FD&C red No. 3; gelatin, NF; glyceryl monooleate; colloidal silicon dioxide, NF; sodium lauryl sulfate, NF; and titanium dioxide, USP.

Each 5 ml of diphenhydramine HCl elixir contains 12.5 mg diphenhydramine HCl with 14% alcohol for oral administration.

Diphenhydramine HCl in the parenteral form is a sterile, pyrogen-free solution available in two concentrations: 10 mg and 50 mg of diphenhydramine hydrochloride per ml. The solutions for parenteral use have been adjusted to a pH between 5.0 and 6.0 either with sodium hydroxide or hydrochloric acid. The multidose Steri-Vials contain 0.1 mg/ml benzethonium chloride as a germicidal agent.


CATEGORIES: Allergic Reactions; Allergies; Angioedema; Bites, Insect; Congestion, Nasal; Congeston, Sinus; Conjunctivitis; Dermatographism; Influenza; Motion Sickness; Parkinsonism; Pharyngitis; Rhinitis; Shock, Anaphylactic; Urticaria; Vertigo/Motion Sickness; Pregnancy Category B; FDA Approved 1946 Mar

FDA Drug Class: Adrenal Corticosteroids; Antihistamines; Antineoplastics; Antitussives/Expectorants/Mucolytics; Antivirals; Cephalosporins; Extrapyramidal Movement Disorders; Nasal Decongestants; Vertigo/Motion Sickness/Vomiting

BRAND NAMES: Allerdryl; Allerdryl 50; Allergia-C; Allergina; Allermin; Amidryl; Banophen; Beldin; Belix; Ben-A-Vance; Ben-Rex; Bena-D-10; Benadryl; Benadryl Elixir; Benadryl N; Benadryl Steri-Dose; Benahist; Benamine; Benapon; Bendramine; Benocten; Benoject; Benylin; Bydramine; Desentol; Diabenyl; Dibenil; Dibrondrin; Difenhydramin; Dimidril; Dimiril; Diphen; Diphenacen-50; Diphenhist; Dolestan; Dytuss; Fynex; Genahist; Histergan; Hydramine; Hydril; Hyrexin; Insomnal; Menna; Noradryl; Norafed; Nordryl; Nytol; Pharm-A-Dry; Pheramin-N; Resmin; Restamin; Sediat; Shodryl; Tega Dryl; Truxadryl; Tusstat; Uad Dryl; Vena; Venasmin; Wehdryl
(Foreign brand names outside U.S. in italics)

COST OF THERAPY: $11.38 (Parkinsonism; Capsule; 25 mg; 3/day; 365 days)

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