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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (D's) » Dorzolamide (ophthalmic)



DESCRIPTION

Trusopt (Dorzolamide Hydrochloride Ophthalmic Solution) is a carbonic anhydrase inhibitor formulated for topical ophthalmic use.

Dorzolamide hydrochloride is described chemically as: (4S-trans)- 4-(ethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide monohydrochloride. Dorzolamide hydrochloride is optically active. Its empirical formula is C10H16N2O4S3·HCl.

Dorzolamide hydrochloride has a molecular weight of 360.9 and a melting point of about 275°C. It is a white to off-white, crystalline powder, which is soluble in water and slightly soluble in methanol and ethanol.

Trusopt Sterile Ophthalmic Solution is supplied as a sterile, isotonic, buffered, slightly viscous, aqueous solution of dorzolamide hydrochloride. The pH of the solution is approximately 5.6. Each ml of Trusopt 2% contains 20 mg dorzolamide (22.3 mg of dorzolamide hydrochloride). Inactive ingredients are hydroxyethyl cellulose, mannitol, sodium citrate dihydrate, sodium hydroxide (to adjust pH) and water for injection. Benzalkonium chloride 0.0075% is added as a preservative.

CATEGORIES, BRAND NAMES

CATEGORIES: Glaucoma; Hypertension, Ocular; FDA Class 1P (Priority Review); FDA Approved 1994 Dec; Pregnancy Category C; Top 200 Drugs

FDA Drug Class: Glaucoma

BRAND NAMES: Trusopt





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