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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (D's) » Doxercalciferol


Doxercalciferol, the active ingredient in Hectorol, is a synthetic vitamin D analog that undergoes metabolic activation in vivo to form 1a,25-dihydroxyvitamin D2 (1a,25-(OH)2D2), a naturally occurring, biologically active form of vitamin D2. Hectorol is available as a sterile, clear, colorless, aqueous solution for intravenous injection. Each milliliter (mL) of solution contains doxercalciferol, 2 mcg; TWEEN® Polysorbate 20, 4 mg; sodium chloride, 1.5 mg; sodium ascorbate, 10 mg, sodium phosphate, dibasic 7.6 mg; sodium phosphate, monobasic 1.8 mg; and disodium edetate, 1.1 mg.

Doxercalciferol is a colorless crystalline compound with a calculated molecular weight of 412.66 and a molecular formula of C28H44O2. It is soluble in oils and organic solvents, but is relatively insoluble in water. Chemically, doxercalciferol is (1a, 3b, 5Z, 7E, 22E) 9,10-secoergosta-5,7,10(19) 22-tetraen-1,3-diol.

Other names frequently used for doxercalciferol are 1a-hydroxyvitamin D2, 1a-OH-D2, and 1a-hydroxyergocalciferol.

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