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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (E's) » Enalapril


When used in pregnancy during the second and third trimesters, ACE inhibitors can cause injury and even death to the developing fetus. When pregnancy is detected, enalapril should be discontinued as soon as possible. See WARNINGS, Fetal/Neonatal Morbidity and Mortality.


Vasotec is the maleate salt of enalapril, the ethyl ester of a long-acting angiotensin converting enzyme inhibitor, enalaprilat. Enalapril maleate is chemically described as (S)-1-[N-[1-(ethoxycarbonyl) -3-phenylpropyl]-L-alanyl] -L-proline, (Z)-2-butenedioate salt (1:1). Its empirical formula is C20H28N2O5·C4H4O4.

Enalapril maleate is a white to off-white, crystalline powder with a molecular weight of 492.53. It is sparingly soluble in water, soluble in ethanol, and freely soluble in methanol.

Enalapril is a pro-drug; following oral administration, it is bioactivated by hydrolysis of the ethyl ester to enalaprilat, which is the active angiotensin converting enzyme inhibitor.

Enalapril maleate is supplied as 2.5 mg, 5 mg, 10 mg, and 20 mg tablets for oral administration. In addition to the active ingredient enalapril maleate, each tablet contains the following inactive ingredients: lactose, magnesium stearate, starch, and other ingredients. The 2.5 mg, 10 mg and 20 mg tablets also contain iron oxides.

Enalapril IV is a sterile aqueous solution for intravenous administration. Enalaprilat is an angiotensin converting enzyme inhibitor. It is chemically described as (S)-1-(N-1(- carboxy-3-phenylpropyl)-L-alanyl)-L-proline dihydrate. Its empirical formula is C18H24N2O5·2H2O.

Enalaprilat is a white to off-white, crystalline powder with a molecular weight of 384.43. It is sparingly soluble in methanol and slightly soluble in water.

Each milliliter of enalapril IV contains 1.25 mg enalaprilat (anhydrous equivalent); sodium chloride to adjust tonicity; sodium hydroxide to adjust pH; water for injection, q.s.; with benzyl alcohol, 9 mg, added as a preservative.


CATEGORIES: Heart failure, congestive; Hypertension, essential; Pregnancy Category C; FDA Approved 1985 Dec; Top 200 Drugs

FDA Drug Classes: Ace Inhibitors; Antihypertensives


BRAND NAMES: Acetensil; Alphrin; Amprace; Analept; Benalipril; Biocronil; BQL; Controlvas; Converten; Convertin; Ednyt; Elfonal; Enaladil; Enalapril; Enaloc; Enapren; Enaprin; Enaril; Envas; Glioten; Hytrol; Innovace; Innovade; Inoprilat; Invoril; Kenopril; Lapril; Lotrial; Minipril; Naprilene; Naritec; Nuril; Pres; Presil; Renavace; Renitec; Renitek; Reniten; Renivace; Repantril; Sintec; Tenace; Unaril; Unipril; Vasopril; Vasotec; Xanef
(Foreign Brand names outside U.S. in italics)

Acetensil (Spain)
Alphrin (Korea)
Amprace (Australia; New-Zealand)
Analept (Bulgaria; Greece)
Benalipril (Germany)
Biocronil (Colombia)
BQL (India)
Controlvas (Spain)
Converten (India)
Convertin (Israel)
Ednyt (Bahamas; Barbados; Belize; Bermuda; Curacao; Guyana; Jamaica; Netherland-Antilles; Puerto-Rico; Surinam; Trinidad)
Elfonal (Korea)
Enaladil (Mexico)
Enalapril (Germany; Spain)
Enaloc (Finland)
Enapren (Italy)
Enaprin (Korea)
Enaril (Korea; Thailand)
Envas (India)
Glioten (Colombia; Ecuador; Mexico; Peru)
Hytrol (India)
Innovace (England; Ireland)
Inoprilat (Indonesia)
Invoril (Benin; Burkina-Faso; Ethiopia; Gambia; Ghana; Guinea; India; Ivory-Coast; Kenya; Liberia; Malawi; Mali; Mauritania; Mauritius; Morocco; Niger; Nigeria; Senegal; Seychelles; Sierra-Leone; Sudan; Tanzania; Thailand; Tunia; Uganda; Zambia; Zimbabwe)
Kenopril (Mexico)
Lapril (Thailand)
Lotrial (Costa-Rica; Dominican-Republic; Ecuador; El-Salvador; Guatemala; Honduras; Nicaragua; Panama; Peru)
Minipril (India)
Naprilene (Italy)
Naritec (Korea; Thailand)
Nuril (India)
Pres (Germany)
Presil (Colombia)
Renavace (Japan)
Renitec (Australia; Austria; Belgium; Benin; Bulgaria; Burkina-Faso; Colombia; Czech-Republic; Denmark; Ecuador; Ethiopia; Finland; France; Gambia; Ghana; Greece; Guinea; Hong-Kong; Hungary; Ivory-Coast; Kenya; Korea; Liberia; Malawi; Malaysia; Mali; Mauritania; Mauritius; Mexico; Morocco; Netherlands; New-Zealand; Niger; Nigeria; Norway; Peru; Philippines; Portugal; Senegal; Seychelles; Sierra-Leone; South-Africa; Spain; Sudan; Sweden; Taiwan; Tanzania; Thailand; Tunia; Turkey; Uganda; Zambia; Zimbabwe)
Renitek (Russia)
Reniten (Switzerland)
Renivace (Indonesia)
Repantril (Indonesia)
Sintec (Taiwan)
Tenace (Indonesia)
Unaril (Taiwan)
Unipril (Colombia)
Vasopril (Bahrain; Cyprus; Egypt; Iran; Iraq; Jordan; Kuwait; Lebanon; Libya; Oman; Qatar; Republic-of-Yemen; Saudi-Arabia; Syria; United-Arab-Emirates)
Xanef (Germany)

COST OF THERAPY: $397.85 (Hypertension; Vasotec Tablet; 5 mg; 1/day; 365 days)

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